| [Objective]Through clinical observation of type 2 diabetes with insulin resistance analysis of patients with symptoms of TCM, and its pathological basis of Chinese medicine can be summed up as the main gas lack, yam poor, phlegm and blood stasis stagnation. Chinese medicine combined through Yiqi Yangyin Huatan Huoxue United Western medicine hypoglycemic agent, and the control and pure Western medicine to explore its in reducing insulin resistance play a role.[Clinical data]Meet the diagnostic criteria for type 2 diabetes, TCM for lack of gas lack stagnation of phlegm and blood stasis in patients with a total of 64 cases of clinical observation study. Selected request:1. Meet 1999 WHO determine the diagnosis of diabetes diagnostic criteria: diabetes symptoms (polydipsia, many food, polyuria, weight loss plus any time plasma glucose≥11.1 or fasting plasma glucose (FPG)≥7.0, or glucose tolerance test (OGTT) plasma glucose 2 hours after meal (2hPG) level of≥11.1 (mmol/L). The above three criteria, as long as there is an up to standard and during the following week and then select any of the three a duplicate check is also in line with standards can be diagnosed as diabetes mellitus;2. Reference to the Chinese Association of Traditional Chinese Medicine Diabetes Branch standards, in line with the lack of gas lack, yam poor. both sputum and blood stasis stagnation, and manifested as dry mouth For drinks, malaise fatigue, gas lazy statement, dizziness Vomiting, re-boring chest, when there is numbness in the limbs or pain, constipation, urination frequency. Thin white or greasy tongue, sublingual venae bruising, thin and Shibuya pulse string;3. Age between 25～70 years old, sex is not restricted;4 Is willing to accept the clinical trials and better compliance;5. Condi ion is steady and plasma glucose nearly 2 weeks iscontroled between: fasting plasma glucose≥7.0 and≤ 13.0 (mmol/L), and(or) plasma glucose 2 hours after meal≥11.1 and≤16.6 (mmol/L);6. Is willing to sign the knows the circumstances of the matter letter of consent.[Method]64 patients were randomly divided into treatment group and control group. Treatment group 36 cases, male 21 cases, 15 cases of female, age 43 ~ 68 years old, the average age of 57.6±3.2 years; the control group 28 cases, male 15 cases, 13 cases of female, age 45 ~ 66 years old, the average age of 54.8±2.5 years old. Two groups of subjects in the maintenance of basic diet and hypoglycemic diabetic medication unchanged, treatment group was given drinking traditional medicine, boiled by water, daily one, sooner or later, the service time, each 250ml. rosiglitazone 4mg Qd; control group: rosiglitazone 4mg Qd. 8 weeks course of treatment, treatment before and after the inspection outcome measures: TCM syndrome, fasting plasma glucose, 2 hours postprandial blood glucose, glycosylated hemoglobin (HbAlc), fasting insulin levels (FINS), insulin sensitivity index (ISI).[Results]1 Two group pre-tretement fasting fasting plasma glucose (FBG), postprandial 2 hours blood glucose (2hPG), fasting insulin (FINS), glycosylated hemoglobin (HbAlc), insulin sensitivity index (ISI) and other indicators of the differences were not statistically significant (P> 0.05 ); two groups before and after treatment, fasting plasma glucose, 2 hours postprandial blood glucose, fasting insulin, glycosylated hemoglobin, insulin sensitivity index and other indicators are improving, (P<0.05 or P<0.01); two groups of comparison, the various indicators, there is statistical difference between Study significance (P <0.05).2 Two groups in all major traditional Chinese medicine symptoms compared to patients taking the five most frequent symptoms in accordance with the effective and ineffective inspection, resulting in dry mouth for drinks, malaise fatigue, stuffy chest weight, constipation, urination frequency and so on up to five emerging. The results from the treatment, the treatment group on improvement of medical symptoms were significantly better than the control group(P<0.05 or P<0.01), difference between the two groups has statistical significance.[Conclusion]Traditional medicine combined medicine Rosiglitazone compared with pure Western medicine Rosiglitazone, to be more effective in reducing type 2 diabetes blood glucose, glycosylated hemoglobin and fasting insulin levels, improve insulin sensitivity index so as to reduce insulin resistance, and to improve the Chinese medicine symptoms have the exact effect. |
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