Change Of Glucogen In Detrusor Of Rats With Partial Bladder Outlet Obstruction And Their Implication

Objective:To explore the change of glucogen in detrusor of rats with partial bladder outlet obstruction(PBOO) and their implication.Materials and Methods:A PBOO rat model was created,a control group had a sham operation for comparison.Individual urodynamic data were obtained weekly,then were killed at different levels of bladder dysfunction.Bladder sections were stained with Periodic Acid-Schiff(PAS) to assess overall glycogen granules density and disposition location, scored from 0 to 3.Results were demonstrated with the 5%,25%,75%, 95%percentile.To analysis the results with the methods of Mann -Whitney U test.Results:Glycogen granules were seen in the detrusor,as their number increased their location expanded from only close to the serosa(glycogen score 1) through the detrusor(score 2) up to the urothelium(score 3); The week of obstruction and bladder humid weight were increased accompany with the glycogen score increased(P＜0.05);The max bladder pressure and volume of the score 2 and 3 group were higher than that in score 0 and 1 group(P＜0.05),there was no statistical significance between score 2 and 3 group(P＞0.05).For the bladder compliance of score 2 was decreased compared to score 1 group(P＜0.05),and was also no statistical significance between score 2 and 3 group(P＞0.05).Conclusions:The occurrence of glycogen deposits in the detrusor near the serosa is an indicator of a bladder that has more potential for functional recovery;This finding may exemplifies a important parameter for functional analysis of bladder detrusor.