Significance Of Cycloxygenase-2 And Multiple Factor In Prognosis Of Bladder Transitional Cell Carcinoma

Objective:To detect the relationships between the expression of COX-2 in BTCC tissue and cancer-specific survival by immunohistochemistry.And to blot the risk factors by analysis potentially risk factors which can result in cancer-specific death,to provide individual schedule for patients' follow-up and treatmentMethods:Collect BTCC patients' information who underwent operation including gender,age, disease category(the initial,the recrudescent,the multiple recrudescent),tumor sharp,tumor number,tumor size,tumor grade,tumor stage,operation mode(TURBT,Partial cystectomy, cystectomy).Detecct the expression of cox-2 in the paraffin block of BTCC patients and follow up the survival time and condiction of recurrence.Utilize Kaplank-Meier survival curve and Logrank analysis to estimate the relationships between the expression of COX-2 in BTCC tissue and cancer-specific survival.Utilize the regression analysis to analyze multiple factor and to establish prognosis index(PI) model according to the analytic result.Results:Cancer-specific survival was shorter in those patients with cox-2 positive compared with those with cox-2 negative(P=0.001＜0.05);patients' age(RR=1.116,P=0.002),tumor stage (RR=4.963,P=0.000) and disease category(RR=2.698,P=0.015) were independently associated with poorer cancer-specific survival in BTCC patients.To divide patients into high risk class,midrange risk class and low risk class according to numerical value of PI.There was statistical significance among the three classes' survival median time(P=0.000＜0.05).their survival median time respectively were 48,48,9 months.Conclusion:1,COX-2 expression has limited prognostic value in patients with bladder TCC. overall survival was shorter in those patients with cox-2 positive compared with those cox-2 negative.2,Age,tumor stage,disease category were independently associated with poorer cancer-specific survival.3,The difference of prognosis index has statistical significance in patients with bladder TCC.The higher the prognosis index is,the shorter the survival time is.it is beneficial to detecte these risk factors for follow-up of patients' prognosis and choice of individual treatment schedule...