Comparative Study Of Serum CystatinC, Serum Creatinine And Urine Microprotein In Glomerular Filtration Rate Measurement In Patients With Chronic Kidney Disease

Objective: To evaluate the applicability of serum cystatin C ,serum creatinine and urine microprotein as endogenous marker for detection of renal disfunction in patients with chronic kidney disease. Methods:Serum samples were obtained from 62 cases who were got with chronic kidney disease, collected from January in 2008 to November in 2008 among our own hospitalized patient. Serum cystatin C concentration was determined by enzyme-linked immunosorbent assay(ELISA),and we record every illness's Serum creatinine(Scr) and urine microprotein (α1-MG,ALB,TRF),and we measured Creatinine clearance rate(Ccr) accord to Cockcroft-Gault equations and our native hospital analysis ,and then we mean the two numerical value as the last numerical values. At the same time, we evaluate the estimated glomerular filtration rate( eGFR) accord to equations MDRD,then we serve eGFR as evaluation criterion,to compare the relation among CysC,Scr,Ccr,α1-MG,ALB,TRF and eGFR. The correlation between eGFR and above parameters were compared,and the areas which under the Receiver Operating Chacteristic curve(AUCROC), and the sensitivity ,they were all used for revaluating the reliability of cystatinC。Results: We found significant correlation between eGFR and cystatin C, Scr, Ccr,r is -0.940,-0.931,-0.935 respectively (p<0.01)。α1-MG,ALB and TRF have a low relationship between eGFR, r is -0.554,-0.484,-0.237 respectively。So the relationship between eGFR and cystatin C was the most strongest。The AUCROC for cystatinC ,Scr ,α1-MG,ALB,TRF are 0 .985, 0.924,0.732,0.682,0.564 respectively, there was significant statistical difference between cystatin C and Scr (P<0.05),and there was also significant statistical difference between cystatin C andα1-MG (P<0.01)。To refer to sensitivity ,the serum cystatin C was the best among the above five parameters,the sensitivity are 96.8%, 91.9%,87.1%,80.6%,79.0%respectively。Conclusion: serum cystatin C determination is an accurate and ready-witted parameter of GFR。It can be a better endogenous marker for detection of early renal disfunction in patients who were with chronic kidney disease than serum creatinine ,urineα1-MG,ALB and TRF。...