Relationship Between Expression Of ER And PR In Placenta And Pathogenesis Of Hypertensive Disorder Complicating Pregnancy

Objective:To study the expression of estrogen receptor(ER) and progesterone receptor(PR) in placenta from normal pregnancy and hypertensive disorder complicating pregnancy and their roles in the pathogenesis of hypertensive disorder complicating pregnancy.Methods:Immunohistochemial technique was used to determine the location and intensity of ER and PR in placenta from 92 patients with hypertensive disorder complicating pregnancy(hypertensive disorder complicating pregnancy group) and 30 normal pregnant women(control group) which are collected form June 2007 to March 2008 in the department of Obstetrics and Gynecology,First Clinical Medical college,Shanxi Medical University.HE staining was used in order to count the number of the vessles.Results:(1)ER mostly were expressed in villous syncytiotrophoblast cells,less in cytotrophblast cells.The intensity of immnostaining was significantly reduced in the severe preecalmpsia group compared with the control group(P＜0.05),(2)PR were expressed in placental syncytiotrophoblast,cytotrophblast cells.Its expression in mild and severe preeclampsia patients were lower than that in control group(P＜0.05).there was no statistical differences between the gestational hypertension and the control group.(P＞0.05).(3)The count of vessels reduced in severe preeclampsia group(P＜0.05).(4)There were positive correlation between the count of vessels in villous and the expression of ER and PR(P＜0.05).There were positive correlation between newborn birth weight and the expression of ER and PR There were positive correlation between placenta weight and the expression of ER and PR(r=0.695, r=0.721,r=0.386,r=0.338;r=0.270,r=0.275,r=0.782,r=0.738);There were correlations between the expression of ER and PR in the control and the gestational hypertension group(r=0.950,P＜0.01;r=0.965,P＜0.01;r=0.864,P＜0.01;r=0.948,P＜0.01)Conclusion:The reduction of ER and PR in human placenta are related to the occurrence and development of hypertensive disorder complicating pregnancy.