The Effect Of Plasma Triglyceride On Platelet Aggregation

Objective:to explore the effect of different plasma triglyceride on the platelet aggregation.Methods:100 patients with hyper-triglyceridemia(TG≥1.7mmol/L) were collected and 68 patients with normal-triglyceridemia(TG＜1.7mmol/L) were collected.The platelet aggregation induced by adenosine diphosphate(ADP) on a 2-channel light aggregometer was measured;Comparing respectively:(1) the PAGT of the patients who had never taken Aspirin in two groups(45,30);(2) the PAGT of the patients who have always taken Aspirin in two groups(55,38);(3)in hyper-triglyceridemia group,the PAGT of the patients with different level of the plasma triglyceride in subunit.Result:The PAGT of the hyper and normal triglyceridemia groups who had never taken As-pirin(45,30) were(75.77±7.15)%,(58.48±8.31)%,respectively,(P＜0.05);The PAGT of the hyper and normal triglyceridemia groups who have always taken Aspirin(55,38)were(56.15±13.65 )%,(48.64±12.75)%,respectively,(P＜0.05);In the hype-triglyceridemia group,the PAGT of the patients in subunit who have always taken Aspirin were:from 1.7 to 2.26mmol/L,(54.04±14.07) %;from 2.26to2.8 mmol/L,(65.86±7.02)%;greater than 2.8mmol/L,(65.86±7.02)%,then,the first and the third subuint were statistically significant(P＜0.05).Couclution:(1)The level of the plasma triglyceride might have an effect on platelet aggre-gation.(2)The inhibit function of the drug,eg.Aspirin on platelet aggregation might be weakened by plasma hyper-triglyceride.