Effects Of Potassium Citrate Supplementation On The Risk Factors Of Stone Forming In Patiens With Upper Urinary Calcium Stone

【Objective】: To investigate the change of the risk factors of stone forming in patients with upper calcium stones after oral administration of potassium citrate .【Meterials and Methods】: Eighty patients of upper urinary calcium stone were randomly allocated into the study group and the control group.The study gro- up includs 40 cases who took potassium citrate 6g/d for two months; the control group includs 40 cases who did not take potassium citrate. 24-hour uri- nary chemistries of study group and control group were measured at baseline and after 2 months of treatment respectively.【Result】: There are 35 cases in study group and 33 cases in cont- rol group who went through the complete investigation. Study group: After 2 months of treatment ,mean urinary citrate increased from 132.60±89.70 mg/24h to 339.84±204.86mg/24h(P<0.05)and mean urinary potassium increased from 29.53±11.55mmol/24h to 58.96±11.25mmol /24h(P<0.05). Mean calcium excretion decreased from 5.67±1.73 mmol /24h to 3.51±1.49 mmol/24h(P<0.05)and Mean urinary oxalate excretion decreased from 121.38±107.81 mmol/24h to 59.53±50.66 mmol/24h(P<0.05). However there was no significant change of the risk factors of stone forming in the control group (P >0.05).【Conclusion】: Potassium citrate can significantly increase urinary citrate,urinary potassium and decrease calcium,oxalic acid of patients with upper calcium stones diseases.Long-term application of Potassium citrate may reduce the recurrence of upper urinary tract calculi.