Effect Of Astilbin Treatment In Rat Aortic Homograft Smooth Muscle Cell Proliferation

Objective: To evaluate the effect of Astilbin treatment in rat aortic homograft smooth muscle cell.Materials and Methods: Rat AVHs were heterotopically allografted onto abdominal aorta from SD rats (n=30) to Wistar rats (n=30). Wistar rats were divided into two groups, Control group and Astilbin group,15 rats each group.Astilbin group were treated with Astilbin(5mg/kg.d.)respectively within 1 weeks after transplantation. Control group were given no Astilbin. 5 rats were sacrificed in batches at 7,14,28 days postoperatively each group. Aortic homograft specimens were obtained for assessing Bcl-2, Bax, histological studies and image analysis.Results: Compared with controls Bax was significantly increased in Astilbin group. Bcl-2 was no obvious change in tow groups. Histological studies showed: In each time the pathological damage in Astilbin group were significantly lighter than the control group, significantly inhibited proliferation of vascular smooth muscle cell.Conclusion: Astilbin treatment at early stage after transplantation may inhibit arterioscleriosis in aortic allograft, the mechanism is related to inhibition of vascular smooth muscle cell proliferation.