Anticancer Drug Camptothecin Derivatives Modification And Characterization

Natural camptothecin has obvious anti-tumor activity, especially for gastrointestinal cancer,leukemia,bladder cancer, such as the effect of stronger activity. Attracted wide attention and research. Therefore carried out by modified camptothecin, find efficient low toxicity of camptothecin derivatives in order to enhance anti-tumor activity of camptothecin is the key. At the conclusion of this article based on the work of their predecessors, using infrared, ultraviolet and other equipment under the help of camptothecin derivatives modified to carry out the research, the main research contents are as follows:1. 20S-hydroxy camptothecin for esterification, synthesis of a series of fatty acid ester, aromatic resin acid camptothecin derivatives, as well as in 7-ethyl camptothecin conducted on the basis of esterification.2. 7 of camptothecin replacement, design a new 7-Et-CPT ,7-Pr-CPT synthesis process, and successfully synthesized 7-Et-CPT ,7-Pr-CPT, high yield, reaction time short.3. Through the IR, UV, HPLC, DSC and other means of analysis of camptothecin derivatives, set up a set of camptothecin derivatives analysis.