Expression Of DLL4 And VEGF In Lung Adenocarcinoma And The Relationship With MVD In Tumor

ObjectiveAngiogenesis depends on the interaction of a variety of promoting factors and inhibiting factors.Vascular endothelial growth factor(VEGF) and Notch signaling pathway take part in this process.This experiment investigates the expression of Notch ligand DLL4 and VEGF in lung adenocarcinoma and the relationship with MVD in tumor.MethodsImmunohistochemical method was used to detect DLL4,VEGF and CD34 protein expression in 80 cases of lung adenocarcinoma(including bronchioalveolar carcinoma and common lung adenocarcinoma) paraffin section tissues.ResultsIn BAC and common AC,DLL4 and VEGF protein stained as brown granules, mainly concentrated in the cytoplasm,the membrane also had a small amount of expression,The expression of DLL4 and VEGF was closely related with tumor diameter,clinical stage,histological grade and lymph node metastasis,DLL4 positive blood vessels in the tissue of common AC ware significant more than that in B AC, VEGF expression also appeared in similar law.MVD in common AC was significantly higher than in the BAC,and the expression of DLL4 and VEGF has obvious consistency.ConclusionsThe expression of DLL4,VEGF in lung cancer tissue was higher than normal lung tissue surrounding the tumor,The expression of DLL4 and VEGF was closely related with tumor diameter,clinical stage,histological grade and lymph node metastasis, DLL4 positive blood vessels in the tissue of common AC ware significant more than that in BAC,VEGF expression also appeared in similar law.MVD in common AC was significantly higher than in the BAC,and the expression of DLL4 and VEGF has obvious consistency.