The Clinical Research Of Ankylosing Spondylitis

Objective:To discuss the regularities of distribution of the familiar differentiation of symptoms and signs for classification of syndrome,the correlation and the change law of physical factors of the pattern of syndrome of the ankylosing spondylitis.Method:Through clinical research transect investigation method,design clinic questionary,carry through clinic information investigation,obtain correlation datas.then apply SPSS10.0 statistical software to analysis data,analyse the regularities of distribution of the familiar differentiation of symptoms and signs for classification of syndrome,the correlation and the change law of physical factors of the pattern of syndrome of the ankylosing spondylitis.principium establish the change law of the ankylosing spondylitis.Result:In the 130 sufferers,male 99,female 31,male female ratio is 3.2:1.In the male sufferers,the moist heat stasis combined the collaterals heat is priority;in the female sufferers,the moist heat stasis combined the asthenia of both qi and blood is priority.The six traditional Chinese medical symptom attack order top down is:the moist heat stasis combined phlegm and blood stasis＞the moist heat stasis combined the collaterals heat＞the moist heat stasis combined the evil factor retent in the body＞the moist heat stasis combined QI-blood weak＞diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat＞the moist heat stasis.among pattern of syndrome the course of disease of female and male has no significance difference(P＞0.05).The course of disease of female and male of the moist heat stasis are all shortest.Discern is 28.63±10.65 and 29.58±12.34,compare with the others has significance difference(P＜0.05 or P＜0.01);the course of disease of the moist heat stasis combined phlegm and blood stasis between male suffers and female suffers is the longest,is 112.91±22.60 and 104.36±21.72,compare with the others has obviously different(P＜0.05 or P＜0.01);the course of disease of the moist heat stasis combined the evil factor retent in the body is also long.the first symptom of the six symptoms of traditional Chinese medicine are mainly pain and early morning stiffness,there is no obviously different between them(P＞0.05).And diseased region are mainly lumbar vertebrae and Lumbosacral vertebrae.and one is 63 pieces (48.5%),30 pieces(23.1%),25 pieces(19.2%).Less onset mainly on cervical vertebrae and thoracic vertebrae.To compare with lumbar vertebrae and Lumbosacral vertebrae has obviously different(P＜0.01).During the six,limbs all can onset.the suffers of diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat have obviously pain.The pain of the moist heat stasis combined the evil factor retent in the body and the moist heat stasis combined QI-blood weak is lighter(P＜0.05).The time of the morning stiffness of the six has obviously different.the time all exceed 60 minutes.The order is the moist heat stasis combined phlegm and blood stasis＞the moist heat stasis combined QI-blood weak＞the moist heat stasis combined the collaterals heat＞the moist heat stasis combined the evil factor retent in the body＞diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat＞the moist heat stasis(P＜0.05).During the active phase diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat and the moist heat stasis is greater than the others(P＜0.05 or P＜0.01).During the intermediate stage the moist heat stasis combined QI-blood weak and the moist heat stasis combined the collaterals heat is greater than the others(P＜0.05).During the advanced stage the moist heat stasis combined phlegm and blood stasis and the moist heat stasis combined the evil factor retent in the body is greater than the others(P＜0.05).Pillow-wall distance,finger-ground distance,thoracic cage-activity,Schober test of the six has obviously different.the pillow-wall distance,finger-ground distance,thoracic cage-activity of the moist heat stasis combined phlegm and blood stasis and the moist heat stasis combined the evil factor retent in the body is greater than the others(P＜0.05orP＜0.01);Schober test of the diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat and the moist heat stasis is greater than the others(P＜0.05).Cacroiliac joint segregation test,pelvis crushing segregation test of the moist heat stasis combined phlegm and blood stasis and the moist heat stasis combined the evil factor retent in the body is greater than the others(P＜0.05).Masccline rate of HLA-B₂₇ of the six syndrome traditional Chinese medicine has no obviously different(p＞0.05).The CRP,ESR,IgA of the diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat,the moist heat stasis and the moist heat stasis combined the evil factor retent in the body is highest(P＜0.05). Cacroiliac joint radiogram appearance of the six has obviously different the diseases caused by exogenous pathogenic factor cold hygrosis stasis transform heat,the moist heat stasis are mainly levelâ…¡,the moist heat stasis combined the collaterals heat and the moist heat stasis combined QI-blood weak are mainly levelâ…¡,â…¢,the moist heat stasis combined phlegm and blood stasis and the moist heat stasis combined the evil factor retent in the body are mainly levelâ…¢,â…£.Conclusion:1.Traditional Chinese medicine to heal AS is on the base of differentiation of symptoms and signs for classification of syndrome,own some ascendancy and feature.the search apply clinical research cross-sectional study to discuss AS common differentiation of symptoms and signs for classification of syndrome onset rule,to open up a new method to symptome investion of AS,and establish foundation for the large scale study of AS.2.During the five symptoms of traditional Chinese medicine of ankylosing spondylitis,the age of onset,course of disease,first symptoms,onset pot,staging,physical and chemical examination,the appearance on the radiotelegram of cacroiliac joint has some different,but follow some rules.3.The study do some analyses of symptoms of traditional Chinese medicine to establish rationale to direct clinical theapy.