Clinical Observation On Therapeutic Effectiveness Of "Man Lv Sheng" Granule In Treatment Of Sinus Bradycardia

Objective:To evaluate the clinical therapeutic effectiveness of Man lv sheng granule in treatment of sinus bradycardia(SB),and its seffe-ctiveness and safety objectively.To provide powerful evidence for Chinese herbal medicine compound preparation in treatment of SB.Method:Divide the 60 patients randomly according to the standard of the illness into 2 groups:30 patients in the treatment group and 30 in the control group,and use Man lv sheng granule in the treatment group and use Xin bao pill in the control group.The treatment lasted for 4 weeks,clinical symptoms;static breath heart rate,effect of ECG,the smallest heart rate in 24 hours and the average heart rate were compared between after treatment and pretreatment stage.Objectives the clinical therapeutic effectiveness of Man lv sheng granule in treatment of sinus bradycardia(SB),and checks its safety.Result:1.Two groups comparedEffect of clinical symptoms:treatment group explicit efficiency: 93.3%and control group explicit efficiency:73.3%.Under the treatment of statistics,the two groups have significant differfence (p＜0.01)Effect of ECG:treatment group explicit efficiency:90%and control group explicit efficiency:53.3%.Under the treatment of statistics,the two groups have significant difference(p＜0.01)2.Change of heart rate comparedWhether resting heart rate,24 hours dynamic ECG most small heart rate and the average heart rate compared,treatment group is better than control group,and the two have significant difference (p＜0.01) 3.Safety index determinationThere is not a case of adverse reaction in treatment group.So the Man lv sheng granule have the characteristics of safety,effective, nontoxic and side effects,and suitable for long-term oral to treat the SB.Conclusion:The Man lv sheng granule which use the method of Warm Yang and Activate Pulse,and benefit qi and activate blood,can improve the clinical symptoms of SB patients,and can improve the patients resting heart rate,24 hours dynamic ECG the most small heart rate and the average heart rate significantly,and have no significant side effects.It is safety and reliable.