Sample preparation is always the critical steps in pharmaceutical analysis. Reverse-phase high performance liquid chromatographic method,a simple,low-cost, the most extensive and highly sensitive method,is very useful and promising.A UV detection or FLD detection can be used merely when the analyte present a suitable chromophore.Pre-column derivatized HPLC is becoming a significant part in sample preparation field when the analyte does not present a chromophore.In this paper,a study and application of determination of diethylene glycol et al by HPLC after precolumn derivatization with p-toluenesulfonyl isocyanate were carried out.â—Simultaneous determination of diethylene glycol and propylene glycol in pharmaceutical products by HPLC after precolumn derivatization with p-toluenesulfonyl isocyanateâ—Determination of water in Traditional Chinese Medicine by HPLC after precolumn derivatization with p-toluenesulfonyl isocyanate...
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