| Epidermal growth factor receptor (EGFR) is highly expressed in lung cancer, especially non-small cell lung cancer , It in turn promote in tumor angiogenesis and tumor cell proliferation, adhesion, invasion and metastasis. Therefore blocking signaling pathway conduction EFGR become hot in targeted therapy of lung cancer. EGFR inhibitors have been used in the current non-small cell lung cancer treatment, with in-depth research and extensive clinical application shows more clearly its selectivity crowd .Gene technology has also so revealed that EGFR mutation and its inhibitor clinical efficacy in the relationship become more and more close. Now the epidermal growth factor receptor inhibitors and mutations in lung cancer treatment would be used for the synthesis. |