| Objective:To analyze therapeutic effect and the prognostic factors of recurrent hepatocellular carcinoma after repeat hepatectomy.Methods:We retrospectively analyzed the clinic pathological data of 48 patients who underwent repeat hepatectomy for recurrent hepatocellular carcinoma from July 1995 to July 2003, overall survival rate, and disease-free survival (DFS) rate were calculated by Kaplan-Meier method, prognostic factors were analyzed by univariate and multivariate analysis.Results:The median survival of 48 patients was 36.4 months. The overall 1-, 3-, and 5-year survival rates were 81.3%, 45.8% and 27.1%, respectively. The disease-free 1-, 3-, and 5-year survival rate was 70.8%, 25.0%, 16.7%, respectively. Univariate analysis showed that primary tumor TNM stage with vascular invasion, recurrent tumor TNM stage with vascular invasion, recurrent tumor size (>5cm) and recurrence-free interval were risk prognostic factors of overall survival; while primary tumor TNM stage,recurrent tumor size (>5cm), recurrent tumor TNM stage, vascular invasion, pathological grading of recurrent tumor, preoperative AFP and recurrence-free interval were risk prognostic factors of DFS. Multivariate analysis showed that recurrence-free interval and recurrent tumor TNM stage were independent risk prognostic factors of overall survival; while recurrence-free interval and recurrent tumor size (>5cm) were independent risk prognostic factors of DFS. Conclusion: Short recurrence-free interval(≤24months),recurrent tumor size (>5cm) and late recurrent tumor TNM stage are indicators of poor prognosis. |
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