Study On Serum G-CSF Level And Its Clinical Significance In Pre-operation And Post-operation Patient With NSCLC

Objective:To determine the serum level of G-CSF in pre-operation and post-operation NSCLC patient,analyze its relations with clinical factors,evaluate the clinical value of G-CSF as a new tumor marker of lung cancer.Methods:Serum value of G-CSF were measured by means of ELISA in 50 patient with NSCLC pre-operation and post-operation. Statistical methods was used to analysis the relations between serum level of G-CSF and clinical or pathology factors,such as the granulocyte counting,histological type,stage and differentiation of tumor.Rusult:Before operation,serum value of G-CSF was(33.3±30.4) pg/ml;after operation,the value is(15.7±13.4)pg/ml.Serum level of G-CSF in post-operation patient with NSCLC was lower than that in post-operation NSCLC patient(P＜0.01).Peripheral white blood cell counting and granulocyte counting also decreased significantly in patient with NSCLC pre-operation and post-operation(P＜0.05).Serum G-CSF level of the patients with NSCLC who is younger than 60 years old is higher than that of the patients older than 60 years old(P＜0.05).The serum G-CSF level related closely with the tumor histology type,the G-CSF level of the large cell lung carcinoma patients is obviously higher than the other two histology types.The G-CSF level of the poorly differentiated carcinoma is higher than that of the well differentiated carcinoma(P＜0.05).The serum G-CSF level is not correlated with the size of primary tumor.The serum G-CSF level in NSCLC patients accompanied with lymph node metastasis is higher than that without lymph node metastasis(P＜0.05).The serum G-CSF level is not correlated closely with the clinical stage of tumor(P＞0.05)Conclusion:Serum level of G-CSF in post-operation patient with NSCLC was lower than that in post-operation NSCLC patient.Serum G-CSF level of the patients with NSCLC related closely with the patient age,tumor histological type,,differentiation and lymph node metastasis. G-CSF may be a new tumor marker in diagnosis and monitoring patients.