Association Of Genetic Polymorphism In Phenylthanolamine-N-methyl Transferase With Essential Hypertension In Hunan Han Population

Objective Essential hypertension(EH) is a mutifactorial disease.The occurrence and development are the results of interactions between a variety of genetic factors and environmental conditions.Investigation on association of genetic factors such as genetic polymorphisms in candidate genes with EH susceptibility will be helpful to understand the molecular mechanism for the disease.In this study,we aimed investigate the association of phenylethanolamine-N-methyl transferase(PNMT)G-390A genetic polymorphism with risk of essential hypertension(EH) in Hunan Han population.Methods A case-control association study was performed in 400 patients with essential hypertension(EH) and 388 normotensive subjects. PNMT G-390A was genotyped by using polymerase chain reaction-restriction fragment length polymorphism(PCR-FRLP).Data were analysed with SPSS software to compare the genotypes and allele distributions in EH and the controls,and unconditional logistic regression was performed to evaluate association of genotypes with EH susceptibility after adjustment for risk factors. Results The genotype frequencies for the -390 GG,GA and AA were 39.3%,50.0%and 10.8%,respectively,in EH patients,and were 43.6%,45.6%and 10.8%,respectively,in normotensive subjects.No significant difference in either genotypic frequency(p=0.433) or allele frequency(p=0.378) of PNMT G-390A between EH patients and normotensives was observed.When stratified by gender,there was significant difference in genotypic frequency(p=0.05) and allele frequency(p=0.046) of G-390A polymorphism between EH patients and nortensives in males,but not in females(p＞0.05).Conclusions The PNMT G-390A polymorphism is possibly associated with EH risk in male of Hunan Han population.