| Objectives:The aim of this study was to to evaluate the effects of Zhibitai capsule on blood lipids and endothelial function in patients with high cardiovascular risk,compared with Atorvastatin.Methods:Eighty three subjects with high risk factors of cardiovascular disease were randomizedly devided into Zhibitai group (n=44) and Atorvastatin group(n=39),and the course of treatment was eight weeks.The levels of blood lipids were assayed by clinical chemistry method.With Doppler ultrasound technique,the flow-mediated dialation (FMD) and intima media thickness(IMT) were measured.Plasma von Willebrand factor(vWF) levels were measured with enzyme linked immunosorbent assay before and after treatment,respectively.Results:1.The levels of triglyeride(TG),total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) were decreased markedly after therapy with Zhibitai and atorvastatin for 8 weeks(P＜0.05),but high density lipoprotein cholesterol(HDL-C) had no significant changes with Zhibitai(P＞0.05 ),whereas HDL-C were decreased markly after therapy with atorvastatin for 8 weeks(P＜0.05 ).The variation of the TC,TG and LDL-C levels had no difference between two group(P＞0.05).2.The FMD was improved significantly in two groups after therapy (P＜0.05).3.Plama vWF levels were reduced markly in two groups after therapy(P＜0.05).4.There was no significant alteration of IMT in two groups(P＞ 0.05).5.There was no correlation between absolute FMD,plasma vWF levels,IMT and blood lipids.There was no correlation between the variation of them.6.The adverse effects of Zhibitai was very mild,and the compliance of patients was very well.Conclusions:Zhibitai has the same good effects on reducing blood levels of TG,TC and LDL-C as Atorvastatin,but no significant negative effect on HDL-C.Besides,It can improve FMD and reduce plama vWF levels to improve vascular endothelial function.The adverse effects of Zhibitai was very mild,and the compliance of patients was very well. |
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