The Effect Of Analgecine Injection On Senile Post Herpetic Neuralgia

Objective:To estimate the effectiveness of Analgecine injection on postherpetic neuralgia,which was administrated by investigating the influence on VAS,QST,QS, and the peripheral T-lymphocyte subsets.Methods:A total of 87 elder outpatients suffering from PHN were enrolled.There were 48 males and 39 females,aging from 60-83 years old and the mean age was 71.78±10.29 years old.All patients were randomly divided into two groups,marked A and B.As the contrast,the patients in group A were treated with the conventional therapy.Whereas patients in group B were given additional 3ml Analgecine injection bid for 15 days.All patients were tested by VAS,QST,QS,and the changes in the peripheral T-lymphocyte subsets when treated and follow-up which were carried out in 7days,15days,and 1 month.Measurement data was presented as mean±SD.Data analysis was tested by t test and x² examination with SPSS11.5.P＜0.05 was accepted as the limit of significance.Results:1.VASOn the 7th day after treatment in group A and B,the score of VAS decreased significantly comparing with the baseline(P＜0.01).As time went on,there was a more significant decrease in group B than group A(P＜0.05,P＜0.01).2.QSTThere were no significant change in differences of QST both in group A and B(P ＞0.05).On the 15th day after treatment in group B,only the score of CS dispersions decreased significantly(t′=5.78,P＜0.05),and after 1 month,there were significantly decrease of the dispersions of all kinds of temperature sensory.However in group A that needs 1 month for the dispersions of CS and WS to decrease significantly(P＜0.05).Besides,the dispersions of QST are bigger in group A than group B after one month(P＜0.05,P＜0.01).3.QSOn the 7th day after treatment in group A and B,the score of QS increased significantly comparing with that before treatment(P＜0.01).As time went on,there was a more significant increase in group B than group A(P＜0.05,P＜0.01).Group B can improve the QS of the PHN patients with a greater degree.4.T-lymphocyte subsetsThere is no significant increase in CD³⁺,CD⁴⁺ percentages and CD⁴⁺/CD⁸⁺ ratio in both groups(P＞0.05).T-cell subsets recovered to normal after 2 weeks in group B.CD³⁺and CD⁴⁺/CD⁸⁺ ratio increased significantly,which needs 1 month in group A.5.Side effectsOne patient in each group suffered slight dizziness and recovered without any treatment.Three patients in group A and four in B felt nausea which did not break the therapy.Throughout this study,the hepatic and nephric function was normal.Conclusion:Analgecine injection can rapidly and significantly alleviate the dispersions of QST and pain,enhance the function of T cells,and improve the QS of the patients with PHN.Analgecine injection is effective and safe in the treatment of postherpetic neuralgia.