A Correlation Analysis Of The Relationship Of Diabeticretinopathy With Serum Pipid

Objective:To investigate the possible relationship of diabetic retinopathy (DR) with serum pipid.Methods:139 cases of type 2 diabetes mellitus(DM) and 40 healthy volunteers were collected from the Second Affiliated Hospital of Dalian Medical University. To observe some index of them, such as duration, fasting blood glucose(FPG), body mass index(BMI), blood pressure(BP), glycosylated hemoglobin(HbA1c), lipoprotein(a) [LP(a)] and oxidized low density lipoprotein(OXLDL) as well as the condition of retina.①The 40 healthy volunteers were considered as normal cases. At the same time,139 DM cases were divided into 3 groups according to prevalence and severity of DR, ie nondiabetic retinopathy(NDR) group, background diabetic retinopathy (BDR) group and proliferative diabetic retinopathy(PDR) group. All of the index were compared between the several groups.②The DM cases were divided into non-obesity group and obesity group according BMI, comparing the severity degree of DR between the two groups.③The DM cases were also divided into non-hypertension group and hypertension group according BP, comparing the severity degree of DR between the two groups.Results:①The levels of FPG, HbA1c,LP(a) and OXLDL in DR(PDR and BDR) cases were significantly higher than the normal cases(P<0.01). And the levels of LP(a) and OXLDL in NDR cases were also higher than the normal cases(P<0.05).②We found that the levels of duration, LP(a) and OXLDL were obviously higher in PDR and BDR groups than in NDR group(P<0.01).③The levels of LP(a) and OXLDL in PDR group were apparently higher than BDR group(P<0.01).④The DR severity degree in obesity group was higher than in non-obesity group(P<0.05).⑤The DR severity degree in hypertension group was apparently higher than in non-hypertension group(P<0.01).⑥The DR incidence in diabetic patients with type 2 diabetes mellitus had something to the levels of LP(a) and OXLDL, and it would become higher and higher with the improving levels of LP(a) and OXLDL obviously(P<0.01).Conclusions:Duration of DM, level of blood glucose, obesity and dyslipidemia, especially the levels of LP(a) and OXLDL, all play an important role in the occurrence and development of DR to some extent. Thus strict control of blood glucose, serum pipid and weight as well as the use of anti-oxidant are equally necessary for diabetic patient.