Anti-HLA And Anti-MICA Antibodies Change Associated With Function Of Transplanted Kidneys In Survival Recipient Of Two Years

Objective: To explore the impact of anti-HLA and MICA antibodies on kidney graft function by dynamic monitoring of two years.Methods: The survival recipient of dead body were undergoing renal transplantation from 2007 to 2008. The recipients of 2007 had 62 cases. The recipients of 2008 had 38 cases. The recipients both 2007 and 2008 had 36 cases. The specificity of anti-HLA and anti-MICA antibodies were detected by Flow PRATM beads. Simultaneously, their serum creatinine levels and clinical data were analyzed.Results:⑴24 recipients had antibody and 38 recipients had not antibody in 2007, the rate of positive was 38.71% (24/62). 19 recipients had antibody and 19 recipients had not antibody in 2008, the rate of positive was 50.0% .⑵17 recipients whose no anti-HLA and anti-MICA antibodies from 2007 to 2008, among them 4 recipients transformed antibodies from negative to positive.⑶Anti-HLA antibodies of recipients in 36 cases: One case changed from negative to HLA-Ⅱantibody 1 year before; One case witnessed no change in the specificity of HLA-Ⅰantibody; 3 cases saw the rise both in specificity of HLA-Ⅱantibody and positive rate 1year later; 1 case experienced the failure of function with antibody of HLA-Ⅰand HLA-Ⅱafter one year.⑷Anti-MICA antibodies of recipients in 36 cases:: 3 cases changed from no antibody to anti-MICA antibody. One case changed from HLA-A1 to anti-MICA antibody; there were no significant change among the other 32 recipients, but the recipients of Scr levels changed rising.⑸The recipients were divided into change and no change groups according to antibody were significant difference(P=0.005). There was significant difference of the Scr levels to compare with change antibody and no change antibody groups(P=0.05).Conclusion: Not only have antibody or no after transplant, but also important time of follow-up change that de novo antibody created in post transplant It is important to detect specificity and positive value of anti-HLA antibodies and anti-MICA antibody regular follow-up post transplant, to take effective therapy for decreasing the occurrence and development rejection on renal allograft.