Study Of The Retinal Nerve Fiber Layer Of Acute Primary Angle-closure Glaucoma By OCT

Objective:To determine the thickness of retinal nerve fiber layer(RNFL) by optical coherence tomography(OCT) in acute primary angle-closure glaucoma (APACG).Methods:26 subjects of APACG patients with the first acute attack(＜6 hours) and 30 normal controls were included in our study.The retinal nerve fiber layer thickness was accessed by OCT in the first day when cornea became clear,1 week,1 month,3 months,6 months after intraocular pressure(IOP) controlled.The RNFLT was compared with the attacked eyes and the normal controls' eyes.Results:The average of APACG patients' RNFLT in the first day(122.144±21.37)μm was thicker than that of normal control(P＜0.01).At 1 week after IOP controlled,the average of RNFL thickness(110.25±17.43 )μm was thicker than that of normal control(P＜0.05).At 1 month after IOP controlled,the average of RNFL thickness(103.344±15.19)μm was little thicker than that of normal control (P＞0.05),there was no significant difference.At 3 months(102.56±14.11)μm and 6 months(101.22±15.54)μm after IOP controlled,the average of RNFLT was little thinner than that of normal control(P＞0.05),there was no significant difference.Conclusion:In the early period,acute rising of IOP cased the edema of retinal,RNFL thickness became thicker,but after treatment and IOP in normal range the RNFL thickness dropped gradually.At 3 months and 6 month after IOP normal,the RNFL thickness tended to be stable,and there was no significant difference with normal control.