Safety And Efficacy Of Anti-Radial Artery Spasm Drugs During Transradial Coronary Intervention Procedure

Objective To systematically evaluate the efficacy and safety of various anti-radial artery spasm (RAS) drugs clinically used in the transradial coronary intervention (TRI) procedure.Method We conducted a large-scale database search. The databases included PubMed (1989-2008), EMbase (1989-2008), Cochrane library (2008, edition 3), Chinese National Knowledge Infrastructure (1989-2008), Wanfang Data (1989-2008), WeiPu Data(VIP) (1989-2008), and Chinese Biomedical Data(CBM)(1989-2008). Results were analyzed using RevMan5.0 software.Result After a vigorous assessment, we selected samples from 7 randomized clinical trials and 1 non-randomized control study from 210 publications for this analysis. Our results showed that, compared to placebos, all vasodilators currently used significantly reduced the risk of RAS. In addition, no severe side effects were found for all the anti-RAS drugs, indicating that all the anti-RAS drugs currently used are generally considered safe and effective for reducing RAS risk. However, the currently available data are not sufficient to provide detailed information on a specific drug, and therefore, more investigations with larger scale and multiple random samples are required.