Repair Of Full-thickness Femoral Condyle Cartilage Defects Using Multiporous Biphasic Composite β-TCP/Magnesium Alloy Scaffold And Adipose-derived Stem Cells

ObjectiveMultiporous biphasic compositeβ-TCP/magnesium alloy scaffold were seeded with autologous adipose-derived stem cells(ASCs) and the constructs were implanted to repair weight-bearing areas of articular osteochondral defects in rabbits.Materials and MethodsAn articular cartilage defect deep to subchondral bone of 3 mm in diameter and 5 mm in depth was created by drilling using a trephine at patellar groove. Our experimental design included three groups:"Autograft", "Scaffold", and "Empty" Histological articular evaluation,μ-CT were conducted to observer the repair of bone and cartilage.ResultsMultiporous biphasic compositeβ-TCP/magnesium alloy scaffold were seeded with autologous adipose-derived stem cells(ASCs) and the constructs are successful to repair weight-bearing areas of articular osteochondral defects in rabbits. Multiporous magnesium alloy scaffold can support and deteriorate.Bone and cartilage can be repaired at the same time.