Clinical Study On Chronicity Serum Hepatitis With "Added Large Amounts Of Cornus Rhinoceri And Rehmanniae Decoction"

Objective This research aims to observe the therapeutic use of added Large amounts of Cornus Rhinoceri and Rehmanniae Decoction to chronicity serum hepatitis patient, such as symptom, Hepatic function, Three of Liver Fibrosis Indexes, b-ultrasound, To discuss its therapeutic effect, to offer some clinical evidences for the curative effect, for better guide to the clinical application.Method A randomized controlled trial was adopted in the clinical study. 120 patients who were diagnosed HBV were divided randomly into a treatment group (60 cases) and a control group (60 cases). The two groups were treated with conventional therapy:took silybinin 25mg per time, three times a day, and Amino acid 6mg per time, Two times a day. While the treatment group were treated with added Large amounts of Cornus Rhinoceri and Rehmanniae Decoction (buffalo horn, rehmannia dride rhizome, Cortex Moutan, Phyllantlais urinaria L. dandelion, honeysuckble, violae, atractylodes) one dose for day, and take orally for two times. The control groups add to placebo. To observe 6 months, The liver function (ALT, AST, GGT, TB) and Three of Liver Fibrosis Indexes, HBV-DNA, b-ultrasound were observed; the two groups were observed to evaluation its clinical effect. Statistical analysis software SPSS10.0 was adopted. T analysis was taken by measurement data, X2 analysis was taken by count data, and then composes the statistical comparison.Result With aspect of improving clinical symptoms of Large amounts of Cornus Rhinoceri and Rehmanniae Decoction, the treatment group fully recovered 43 cases (75%), compared with the control group(30 cases,54%), there was superior difference(P<0.05) at 4 weeks. there was no superior difference between the two groups at 2 weeks(P>0.05), While the treatment group was superior to the control group at 4 weeks. With effect in Liver Fibrosis Indexes two groups were both degraded in Liver Fibrosis Indexes(ALT, AST, GGT, TB), the treatment group was superior to the control group (P<0.05).With effect in Three of Liver Fibrosis Indexes two groups were both degraded in HA, LN, CIV. The treatment group was superior to the control group (P<0.05).HBV-DNA effective While the two groups both have no turning negative, in the HBV-DNA decrease 2logcopy aspect, the rate of markedly improved of the treatment group was the rate of effective was 27.5%, compared with the control group (54%), there was superior difference (P<0.05).With aspect of b-ultrasoundwere, there was no superior difference between the two groups at Vena portalis hepatic, splenic vein, internal diameter and the thickness of spleen (P> 0.05), never in prior treatment No after treatment. To hint there have no obviously curative effect.Conclusion Large amounts of Cornus Rhinoceri and Rehmanniae Decoction improve the clinical symptoms, resisting injury the liver cells, decrease the level of HA, LN, CIV, could restraint the replication of HBV-DNA, There are no adverse reactions. The treatment is safe and effective.