| Object ive1. The clinical efficacy of ozone autohemotherapy on acute cerebral infarction was evaluated by NIHSS, improved Rankin Scale (mRS) index, symptom scores of Wind-Phlegm Stasis Syndrome, so that a new treatment of cerebrovascular disease could be provided.2. For providing more valuable and objective information about the treatment and prognosis of ozone autohemotherapy on acute cerebral infarction, FA (fractional anisotropy) was assessed with Diffusion tensor imaging (DTI) for the quantitative assessment of cerebral lesions and related issues.3. The mechanisms of ozone autohemotherapy on acute cerebral infarction and its distant lesions were explored and the safety was evaluated according to detections of antioxidant indexes (SOD, MDA, NO) and routine blood test.MethodsSixty patients with acute cerebral infarction admitted in our hospital were selected in the study which had the single lesion of subcorticals involving the internal capsule at the unilateral middle cerebral artery area. They were diagnosed as "stroke of the meridian (Phlegm Wind Resistance Type)" in traditional Chinese medicine through syndromes diagnosis. They were randomized into two equal groups (n=30):treatment group and control group. All the patients in the two groups received conventional therapy (once at night with 0.1-0.3g Aspirin enteric-coated tablets and 0.45g Xueshuantong Injection, once on day only with 0.1-0.3g Aspirin enteric-coated tablets). Meanwhile, in ozone treatment group, the patients also received ozone autohemotherapy (once a day, ten days as a course). After the course of treatment, the differences were compared on the NIHSS, Rankin Scale (mRS) index, Wind-Phlegm Stasis Syndrome scores, DTI, DWI and antioxidant indexes (SOD, MDA, NO) between the two groups.Result1.After treatment 10 days later, the NIHSS and mRS indexes of the two groups decreased and the different decrease levels between the two groups had statistical significance (P＜0.05); The total effective rates of treatment group and control group were 93.3% and 83.3%. And the difference had significance (P＜0.01).2. After treatment 10 days later, Wind-Phlegm Stasis Syndrome scores in both groups decreased, and the different decrease levels between the two groups had statistical significance (P＜0.05).3. Before treatment, the FA values of cerebral lesions and contralateral cerebral peduncle were compared and the difference had statistical significance (P＜0.01), which showed the early onset of distant lesions. After treatment 10 days later, the FA values of cerebral lesions and ipsilateral cerebral peduncle in both groups also decreased but the decrease in treatment group was lower than that in control group. The decrease difference had statistical significance (P<0.05). The FA image showed that the signals of cerebral lesions and ipsilateral cerebral peduncle were weaker than that of contralateral cerebral peduncle and they weakened more obviously along with the progression. The signal of treatment group weakened less than that of control group. The DTT showed that after treatment 10 days later the Corticospinal tract of cerebral lesions of some patients in both groups were less than that of before treatment. However, the control group was more obviously.4. Before treatment and after treatment 10 days later, the size of lesions had no significant difference between the two groups (P＞0.05).5. Ten days later, the contents of SOD and NO in plasma of both groups increased. The increase in treatment group was higher than that in control group, and the increase difference had statistical significance (P＜0.05). The contents of MDA in plasma of both groups decreased. The decrease in treatment group was higher than that in control group, and the increase difference had statistical significance (P＜0.01).6. After treatment, all the patients in both groups had no adverse reactions with medicine, thus it was very safe.ConclusionOzone autohemotherapy could decrease neurological deficit of patients with acute cerebral infarction and had definite efficacy on stroke of phlegm wind resistance type, as well as certain improvement and intervention on distant lesions secondary to infarction. Advanced DTI was used for observing the patients before and after treatment as to provide objective and valuable image data for ozone autohemotherapy. The study showed that ozone autohemotherapy could increase the content of SOD and NO and decrease the content of MDA, relieving the inhibition of anti-free radical enzymes and decreasing the lipid peroxidation rate and extent. It has speculated that the effects of antioxidant free radical damage is one of the mechanisms of ozone autohemotherapy on acute cerebral infarction. Ozone autohemotherapy has definite efficacy and high safety, thus it is worthy of further study and discussion. |
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