Clinical Research Of Graves Disease With Prunella Spike Oral Liquid Combinating Antithyroid Drugs

ObjectiveObserved Prunella oral liquid tapazole Chinese Medicine of the heart and liver Huo type are diffuse toxic goiter (Graves disease) clinical efficacy, as well as related laboratory parameters of patients for the clinical treatment of diffuse toxic goiter in Integrative Medicine to provide the basis for optimization programs.MethodDiagnosis and treatment of thyroid diseases by Chinese guides and TCM standards, select from September 2009 to February 2010 at the Hospital of Guangdong Province during the patient's heart and liver Huo-type 60 patients with GD, by visiting sequence were randomly divided into two groups. The basis for Western medicine in treatment and non-drug therapy (such as changing bad habits, adequate rest, better nutrition, etc.) based on the divided into three Tazobactam treatment group (control group) and 30 cases of oral liquid combined with methimazole Prunella treatment group (treatment group) 30 cases. Two groups in gender, age, condition etc. Statistically, the differences were not significant (P> 0.05), comparable. Application of clinical symptom score sheet, score card and goiter, exophthalmos integral scales in the two groups before treatment and three months after the evaluation one, while other laboratory indicators of thyroid function observed changes, and general physical examination before and after treatment items (such as body temperature, heart rate, blood pressure, etc.), three conventional, liver and kidney function, ECG and other safety indicators. Will collect all relevant information into the computer, and set the input quality control procedures to ensure the quality of data entry. Accurate input data, using SPSS software (version 13.0) for statistical analysis. Measurement data between groups and within groups were analyzed using ANOVA and paired t test, chi-square test with count data, grade data using Kruskal-wallis test analysis. And statistical analysis of the results.ResultsAfter statistical analysis, based on the situation of patients before treatment, no significant differences between comparable. After three months of treatment, the two groups in clinical symptoms and signs, thyroid function before treatment than those in the situation has improved (P<0.01), with statistical significance. Statistical analysis showed that the total effect of the treatment group than the control group (P<0.05). After treatment than in improving the neck swelling, palpitations, restless, irritability, there are significant differences (P<0.05), the treatment group than the control group. Signs in the treatment group goiter therapy than the control group (P <0.05). However, after treatment, thyroid function, improve the degree of exophthalmos, no significant difference between the two groups. Before and after treatment, the safety of the two groups showed no significant change occurred in the course of treatment were not significantly associated with the use of Chinese medicines adverse reactions.ConclusionPrunella oral liquid methimazole treatment of diffuse toxic goiter, may improve symptoms and signs in patients with hyperthyroidism. In improving the clinical symptoms (such as palpitations restless, irritability, neck swelling), increased total effective than the simple use of the edge of methimazole treatment, and no obvious side effects, safety, good, worthy of clinical.