The Effect Of Spicy Food For The Allergic Contact Dermatits Of Three Perfumes

Objective:Broad definition cosmetic dermatitis is that all the Skin changes was caused by the cosmetics.but narrow cosmetics was only include Allergic Contact Dermatitis and Irritant Contact Dermatitis. We usually talk the cosmetic dermatitis is allergic contact dermatitis.The common allergens is the perfume and antiseptic. Recent research had shown that spicy foods could enhance the body local reactions.Present research is aimed to study the effects of spicy foods on epidermis stimulation induced by cinnamic aldehyde, isoeugenol and geraniol. so as to provide the data for the diagnosis and treatment of related diseases.Methods:10%pepper fluid(10ml/kg weight) and degree alcohol blend(10ml/kg weight)were used to feed the mice as the spicy food once a day. Saline were used as control group once a day.7 days later, mice's symptom were observed and scored. When the pungent model was complented, the mice will be injected in the abdomen with three diffent spice stock solution., this process is the induced process of the allergic reaction. When finished the induced reaction in the 7 days,1% cinnamic aldehyde,4% isoeugenol and 4% geraniol were applied on the skin once for single skin., this process is the excitation process of the allergic reaction.After 24h,48h,72h, cutireaction were observed and scored according to《Cosmetics health norm》,and do the histological detection.Results:Compared with control group, the mice experimented with the spicy food appeared obvious signs of stimulation, which has statistical significance (P<0.01); The results of multiple skin stimulation tests showed that group pungent and controlhad mild, midrange and severe erythema,some had dropsy. Average histological scores, between the pungent group and the control group there is significant difference (P<0.05); In comparison with three perfumes, between the cinnamic aldehyde group and the geraniol group there is significant difference (P<0.01), between the cinnamic aldehyde group and the isoeugenol group there is no significant difference. between the isoeugenol group and the geraniol group there is significant difference (P<0.01); vacancy group and geraniol group,(pungent) geraniol group there are significant difference. (P＜0.01) conclusion:In accordance with the dose used in the experiment, pepper and alcohol blend induced in mice can have a pungent to stimulate the signs. In this condition, Allergic Contact Dermatitis would be aggratated by the three perfumes. cutireaction intensity strength was concerned with kinds of the spice.The intensity strength of sensitization was also changed in the stimulus of the pungent substance. we should pay attention to the diagnosis and treatment of spicy food on the impact of Contact Dermatitis.