Study On TCM Syndrome Characteristics Of The Patients With Primary Liver Cancer Before And After Operation And TACE

[Objective]To observe the syndrome of the distributions and changes in circumstances and reveal the syndrome changes characteristics in Traditional Chinese Medicine(TCM) of primary liver cancer patients before and after operation and TACE, providing an objective basis for TCM syndrome differentiation and treatment after operation and TACE.[Method]Using self controlled study, baseline data according to "registration form of pri-mary liver cancer therapy" and TCM syndrome according to "observation table of primary liver cancer",which was made by department of Traditional Chinese Medici-ne,Changhai Hospital, meeting the inclusive criteria of the 63 cases of liver cancer surgical patients and 106 cases of TACE patients who were included in this study.The observation of liver cancer TCM syndrome was divided into twice, respectively,1～3 days before surgery and 7～10 days after operation; 1～3 days before TACE and 3～5 days after TACE. After observing,the contents of "registration form of primary liver cancer therapy" and "observation table of primary liver cancer" would be by input Epidata software to manage data,and finally the data was put into SPSS statistical analysis.[Result]1. The result of single and compound syndromes of the distribution before and after operation:after operation changing greatly in constituent ratio were blood stasis syndrome and qi deficiency syndrome.Blood stasis syndrome decreased by 6.3% compared with these before operation, qi deficiency syndrome increased by 5.3% compared with these before operation,statistically difference between before and after operation(P<0.01).Qi stagnation syndrome,damp syndrome,blood deficiency syndrome increased by 1.5%,2.3%,1.8%, respectively,compared with these before operation.excess-heat syndrome,yin deficiency syndrome,yang deficiency syndrome decreased by 0.4%,2.2%,1.0% compared with these before operation.There were no statistical difference between before and after operation(P>0.05). After operation changing greatly in constituent ratio were hepatic blood stagnation syndrome which dreased by 5.4% and spleen deficiency syndrome which increased by 4.2% compared with these before operation, statistically significant difference before and after operation (P<0.05).After operation liver-qi stagnation syndrome, damp-heat brewing syndrome, liver-blood deficiency syndrome increased by 1.5%,0.9%,0.2%.yin deficiency of liver and kidney syndrome, yang deficiency of spleen and kidney syndrome dreased by 1.3%,0.1%. There were no statistical difference before and after operation in this five compound syndromes (P>0.05).2. The result of single and compound syndromes of quantitative scoring before and after operation:qi deficiency syndrome increased after operation, statistically difference between before and after operation(P<0.01). There were no statistical difference before and after operation in qi stagnation syndrome,blood stasis syndrome,excess-heat syndrome,damp syndrome,blood deficiency syndrome,yin deficiency syndrome,yang deficiency syndrome (P>0.05). Hepatic blood stagnation syndrome decreased and spleen deficiency syndrome increased after operation, statistically significant difference between before and after operation(P<0.05). There were no statistical difference before and after operation in liver-qi stagnation syndrome,damp-heat brewing syndrome,yin deficiency of liver and kidney syndrome,liver-blood deficiency syndrome,yang deficiency of spleen and kidney syndrome (P>0.05).3. The result of single and compound syndromes of the distribution before and after TACE:after TACE changing greatly in constituent ratio were qi deficiency syndrome and yang deficiency syndrome, increased by 4.1%,2.6% compared with these before TACE,statistically significant difference between before and after TACE(P<0.05).Qi stagnation syndrome,blood stasis syndrome,yin deficiency syndrome decreased by 3.6%,2.8%,3.9% respectively compared with these before TACE.Excess-heat syndrome,damp syndrome,blood deficiency syndrome increased by 0.9%,0.8%,1.9% compared with these before TACE.There were no statistical difference between before and after TACE (P>0.05). After TACE changing greatly in constituent ratio were hepatic blood stagnation syndrome,damp-heat brewing syndrome, spleen deficiency syndrome,yin deficiency of liver and kidney syndrome, liver-blood deficiency syndrome and yang deficiency of spleen and kidney syndrome. Hepatic blood stagnation syndrome,yin deficiency of liver and kidney syndrome decreased by 7.9%,7.0% compared with these before TACE. Damp-heat brewing syndrome,spleen deficiency syndrome,liver-blood deficiency syndrome and yang deficiency of spleen and kidney syndrome increased by 3.4%,9.0%,3.1%,3.2% compared with these before TACE, statistically significant difference before and after TACE (P<0.05).After TACE liver-qi stagnation syndrome dreased by 3.7%. There were no statistical difference before and after TACE (P>0.05).4. The result of single and compound syndromes of quantitative scoring before and after TACE:qi stagnation syndrome decreased after TACE, excess-heat syndrome,qi deficiency syndrome,blood deficiency syndrome and yang deficiency syndrome increased after TACE, statistically difference between before and after TACE(P<0.01).There were no statistical difference in blood stasis syndrome,damp syndrome and yin deficiency syndrome before and after TACE (P>0.05).Hepatic blood stagnation syndrome decreased,damp-heat brewing syndrome ,spleen deficiency syndrome and liver-blood deficiency syndrome increased after TACE,statistically difference between before and after TACE (P<0.01). There were no statistical difference before and after TACE in liver-qi stagnation syndrome,yin deficiency of liver and kidney syndrome,yang deficiency of spleen and kidney syndrome (P>0.05).[Conclution]1. Blood stasis syndrome(hepatic blood stagnation syndrome)decreased and qi deficiency syndrome(spleen deficiency syndrome)increased after operation of liver cancer patients;after operation TCM syndrome differentiation should pay attention to the therapeutic methods of strengthening spleen and replenishing qi at the same time.2. Qi deficiency syndrome(spleen deficiency syndrome),excess-heat syndrome (damp-heat brewing syndrome)and blood deficiency syndrome(liver-blood deficiency syndrome) increased and hepatic blood stagnation syndrome decreased after TACE of liver cancer patients;after TCAE TCM syndrome differentiation should pay attention to the therapeutic methods of clearing heat and disinhibiting dampness,supplementing qi and blood at the same time.