Administration Of Vasopressin Combined With Epinephrine During Cardiopulmonary Resuscitation Evaluating Clinical Effects

Objective:To evaluate the effect of vasopressin combined with epinephrine during cardiopulmonary resuscitation thorough S-100 protein changing,end tidal CO2,restoration of spontaneous circulation(ROSC) needing time and rate of successful cardiopulmonary resuscitation.Methods:80 patients with cardiac arrest who obviously have no defferences in their ages,sexes and category of diseases were divided into two groups randomly, one is the treatment group(vasopressin combined with epinephrine group),the other is the control group(epinephrine gruop).Each group consists of 40 patients. The value of serum S-100 protein were detected respectively at 0h,0.5h,1h,2h after cardiopulmonary resuscitation by ELISA. At the same time, to research end tidal CO2,the time of ROSC and rate of successful cardiopulmonary resuscitation. To evaluate combination of vasopression and epinephrine during cardiopulmonary resuscitation by serum S-100 protein changing,end tidal CO,the time of ROSC and rate of successful cardiopulmonary resuscitation. Measurement data take t test and numeration data take chi square test. According to statistics, we analyze data and draw a conclusion.Result:At the beginning of cardiopulmonary resuscitation, the value of serum S-100 protein in the control group does not differ from that in the treatment group[the control group:0.09±0.01(μg/l), the treatment group: 0.10±0.09(μg/l)], but the X±s of serum S-100 protein in the treatment group at 0.5h,1h,2h respectively is 0.56±0.34(μg/l),1.56±0.55 (μg/l),3.5±0.91(μg/l), serum S-100 protein in the control group 2.02±0.57(μg/l) 3.10±0.62 (μg/l),4.33±0.62 (ug/l), at 0.5h,1h,2h after cardiopulmonary resuscitation,the average value of serum'S-100 protein in the treatment group significantly differs from that in the control group respectively. The average value of serum S-100 protein in the treatment group is obviously lower than that in the control group respectively. At the beginning of cardiopulmonary resuscitation, the value of end tidal CO2 in the control group does not differ from that in the treatment group[the control group: 1.04±0.83(mmHg),the treatment group:1.18±0.80(mmHg)], but the x-±s of end tidal CO2 in the treatment group at 0.5h,1h,2h respectively is 17.38±9.39(mmHg),22.45±12.46 (mmHg),24.40±13.55 (mmHg),that in the control grou9.25±5.09 (mmHg),13.93±9.73 (mmHg),15.85±11.37 (mmHg).At 0.5h,1h,2h after cardiopulmonary resuscitation,the average value of end tidal CO2 in the treatment group significantly differs from that in the control group respectively. At the same time, the average times of ROSC in the treatment group[8.37±6.34 (min)] is obviously shorter than that in the control group[19.71±14.81 (min)]. The rate of successful cardiopulmonary resuscitation in the treatment group at0.5h,1h,2h is 77.5% 65%,47.5%respectively,that in the control group is 45%,27.5%,15%respectively.The rate of successful cardiopulmonary resuscitation in the treatment group is obviously higher than that in the control group respectively. These statistics in the treatment group are significantly different from those in the control group.Conclusion:The clinical curative effect in the treatment group excels that in the control group, and vasopressin combined with epinephrine improve the time of ROSC and rate of successful cardiopulmonary resuscitation.So vasopressin promises during cardiopulmonary resuscitation and yet more researches will be carried out for the clinical curitive effect.