Expression Of S100A2 And P53 Protein In Non-small Cell Lung Cancer

Objective To investigate the expression of S100A2 and p53 protein in non-small cell lung cancer and their relationship with clinical pathological features. To explore their roles in carcinogenesis and progression of lung cancer and evaluate their clinicopathologic significances. Methods Immunohistochemical technique was used to detect the expression levels of S100A2 and p53 protein in 60 non-small cell lung cancer and normal lung tissues of 15 patients. Results 1. The positive rate of S100A2 protein in non-small cell lung carcinoma(70.0%) was higher than in the normal tissues(20.0%) (P<0.01). And the positive rate of S100A2 protein inⅠstage and (ⅡandⅢ) stage was 43.7% and 79.5% respectively, the difference was significant (P<0·01). The positive rate(82.8%) of S100A2 protein in the lymph node-positive grope was higher than the rate(58.1%) in the lymph node-negative grope (P<0.05). 2. The positive rate of p53 protein in non-small cell lung carcinoma(63.3%) was higher than in the normal tissues(26.7%) (P<0.01). And the positive rate of p53 protein inⅠstage and (ⅡandⅢ) stage was 12.5% and 81.8% respectively, the expression levels of p53 protein was significantly higher in cancer specimens with (ⅡandⅢ) stage than that inⅠstage(P<0·01). The expression level of p53 protein was higher significantly in low differentiated group(79.2%) than well and moderate differentiated group(52.8%) (P<0.05). The positive rate(82.8%) of p53 protein in the lymph node-positive grope was higher than the rate(45.2%) in the lymph node-negative grope (P<0.05). The positive rate of p53 protein in squamous-cell lung carcinoma(78.1%) was higher than in the adenocarcinoma(46.4%) (P<0.01). 3. The expressing of S100A2 protein and p53 protein were not correlated with gender , age, tumor location, pleural invasion, vascular invasion (P>0.05). 4. Relationship was not be found between the expressing of S100A2 protein and p53 protein (P>0.05). Conclusion 1. S100A2 play an important role in the carcinogenesis and progression of lung cancer. S100A2 might be an important biomarker in the judgement of the biological behaviour of NSCLC. 2. The expressing rate of P53 protein was high in the tissues of NSCLC, which indicates that P53 is closely related to the carcinogenesis and progression of NSCLC. 3. S100A2 and p53 protein maybe play joint action in the carcinogenesis and progression of NSCLC. Investigating the expressing of S100A2 and P53 protein combinedly in the lung cancer is not only more significant than investigating only one of them , but also provides a new theory basis for explore the biomarker of NSCLC.