The Neuroendocrine Hormone Changes In Retroperitoneal Laparoscopic Operation

Objective: To investigate changes of neuroendocrine hormone in retroperitoneal of laparoscopic patients,Research in this area is now mainly concentrated in the open and laparoscopic surgery in a larger time period before and after the test compared to the previous value of, And controversial, For a smaller perioperative period of time trend study of hormone less perioperative period in this experiment on a small period of time to implement detection of hormonal changes, hormonal changes in a more detailed understanding of trends, provide the basis for clinical data. Methods: 23 cases were observed during retroperitoneallaparoscopicoperation, aged 23 to 69 years old, 13 males and 10 females. All cases, no severe preoperative liver and kidney dysfunction, without diabetes, angina, myocardial infarction history, no high blood pressure, thyroid disease, blood disease and other metabolic disorders.Preoperative not used drugs such as glucocorticoid hormones for more than two weeks, in which renal cysts in 15 cases, ureteral stones in 6 cases, 1 case of adrenal cyst, chyluria in 1 case. All patients were B-, CT and other tests confirmed that the surgery carried out under general anesthesia, operative time were around 1h, post-operative pathology. Respectively, of pre-pneumoperitoneum 10min (Ta), pneumoperitoneum after 30min (Tb), pneumoperitoneum pneumoperitoneum after 60min or coming to an end (Tc), after the demolition of gas 30min (Td), and 60min time (Te)elbow venous blood collected, centrifuged Machine separation of serum, -80℃refrigerator prepared test. Application of radioimmunoassay in the serum total T3, T4, TSH, cortisol (COR), insulin (INS), glucagon (GLU) levels, data applications SPSS13.0 software, using single-factor repeated measurements analysis of variance of data , measurement data with the?x±s.Results: Intraoperative cortisol hormones in 30min and 60min after pneumoperitoneum compared with preoperative 10min and 60min after operation was significantly higher (P <0.05), although thyroid hormone T3, but the various points of the fluctuations was no statistically significant, T4, TSH surgery no significant changes in insulin pneumoperitoneum than after 30min and 60min before and after the detection point has been increased, but there was no significant difference in glucagon had no significant fluctuations.Conclusion: This study suggests that: urology patients during laparoscopic surgery-related changes in neuroendocrine hormones can see that the existence of the stress response prompts; surgery was significantly higher in the hormone cortisol can be seen, but after 60min of pre-pneumoperitoneum compared with no significant intraoperative thyroid hormones, no significant changes in T3, T4, TSH, INS and GLU hormone, suggesting that CO2 pneumoperitoneum in laparoscopic surgery, though the stress response but the strength is limited, the concept of "minimally invasive" but not "non-invasive" point of view.