Clinical Research Of Alpha-Blocker Treating Chronic Prostatitis

Objetive:To observe the the National Institutes of Health-Chronic prostatitis symptom index (NIH-CPSI) symptom score and prostate massage fluid leukocyte counts in EPS of experimental group and control group before and after oral medication treatment of chronic prostatitis, and preliminarily study the therapeutic effect and mechanisms of alpha-blocker treating chronic prostatitis.Method:Collect 90 patients who were diagnosed with typeâ…¢a orâ…¢b chronic prostatitis between January and December of 2009 in the Second Hospital of Shandong University Clinics of Urology and Andrology. Using the random number table, patients were randomly divided into two groups with 45 cases of each group. Then the experimental group were given oral a-receptor blockers, antibiotics and Chinese patent medicines, and the control group were only given oral antibiotics and Chinese patent medicines, course of treatment was 8 weeks. Before and after treatment, the American National Institutes of Health prostatitis symptom questionnaire (NIH-CPSI) survey and expressed prostatic secretion (EPS) routine examination were recorded. Patients were compared the NIH-CPSI symptom score and total score changes before and after the treatment, and compared expressed prostatic secretion(EPS) white blood cell counts, to observe the effect of drugs on chronic prostatitis.Result:Before treatment, patients in the age composition of experiments, disease severity, NIH-CPSI score and the white blood cell count of EPS, there was no significant difference. Then given 8 weeks'treatment of drugs, there was significant difference in disease severity, NIH-CPSI score and the white blood cell count of EPS than before.Compared the effect of drug between two groups:Significant efficiency between experimental and control group were 60.87% and 32.50%, effective percentage were 93.48% and 77.50%.After treatment, the effect of treatment between experimental group and control group was significantly different. Disease severity of the experimental group, people with severe disease accounted for 21.74%(10) and with mild accounted for 28.26%(13),there was only 5 people with severe accounted for 10.87%and 27 with mild accounted for 58.70%; but people in control group with with severe accounted for 22.50%(9)and with mild accounted for 27.50%(11), there was only 5 people with severe accounted for 15.00% and 15 with mild accounted for 37.50%. Before and after treatment, there were no significantly differents in scores of pain or discomfort, quality of life and the NIH-CPSI total score between two groups; while there was significant differences in score of urinary symptoms. There was significant differences in white blood cell count both in two groups, but decrease of white blood cell in experimental group was more significant than control group.Conclusion:Drugs in both two groups can decrease the severity of disease as a result of improving symptoms scores of NIH-CPSI in patients with chronic prostatitis, and reducing the WBC count of EPS.In short, a-receptor blockers can increase the treatment effect of antibiotics and Chinese patent medicines.It had effects both in improving the symptoms of chronic prostatitis of the NIH-CPSI score and reducing the counts of white blood cell in EPS,and it alleviated the urinary symptoms more significantly.