Primary Hepatic Amyloidosis: A Case Report

Amyloidosis is not a single disease but a term for diseases that share a common feature: the extracellular deposition of pathologic insoluble fibrillar proteins in organs and tissues that can compromise organ function. Amyloid can be deposited at the local or systemic, and the organ commonly involved are the kidney, heart, liver, spleen, gastrointestinal tract, skin and other tissues. When liver is involved, amyloid deposited at hepatic intercellular is termed as hepatic amyloidosis. Hepatic amyloidosis is a part of systemic amyloidosis. In recent years, kidney, heart, skin, throat and bladder amyloidosis are reported, while hepatic amyloidosis is rarely reported. Here we report a case of primary hepatic amyloidosis. A 63-year-old female patient with hepatosplenomegaly as the main manifestation, was confirmed the diagnosis of hepatic amyloidosis through positive liver biopsy stained with Congo red.