Study On Relativity Of GDM Pregnant Women's Mental State With Plasma 5-HT Level

ObjectiveGDM is a common complication of gestation, and its incidence increases year after year. It is first found and diagnosed in obstetrical examination, pregnant women lack psychological preparation, and become anxious, depression because of sudden misfortune. Study showed that pre-natal mental health status and the occurrence of postpartum depression have significant correlation. First diagnosed patients who lack disease knowledge will have various harmful psychological problems, these negative emotion can make growth hormone, stress hormone secretion increases, leads blood sugar increases, makes disease worse, at last forms a vicious circle. At present, the internal and overseas'people pay attention to gestation women's psychogenic hygiene, however, there is few study on GDM pregnant women's mental state. Symptom checklist-SCL90 is a kind of most famous psychogenic health checklist, it is used to test in some crowd which people may have psychologic obstacle, somebody may get which psychologic obstacle and the obstacle's severity. A lot of studies shows that when someone has low 5-HT's function and activity, he will appear depressed, apprehension, motor inhibition, decreased food appetite, dyssomnia, rhythm disturbance and endocrine functional disorder and so on. But there is no correlated study whether 5-HT has relation with GDM patients mood disorder, whether GDM has some relationship with mood disorder, whether the relationship is related with 5-HT content. The article discusses healthy and GDM pregnant women's mental state, detects the correlation of 5-HT content variation tendency in blood with GDM pregnant women's mood status. This will provide theory basis for perinatal mother-fetus safe, avoiding gestation mood disorder and gestation complication and worse delivery end. ate the relativity of 5-HT change tendency with GDM and healthy pregnant women's mental state.MethodI use case control method to choose GDM and healthy pregnant women as study object, Reference to Le Jie edited version 7, "Obstetrics and Gynecology" diagnostic criteria of the initial diagnosis of GDM mothers, single birth, no other complications and complications of patients, a level above junior high school. For the same period in the control group of age, gestational age, educational level similar to the early non-maternal complications and complications. There was no serious physical disease and mental illness. A total of 100 cases,38 cases of GDM group,62 cases of the control group. After get final diagnosis I use symptom checklist(SCL90) to research psychogenic health status, the screening result is masculine when SCL90>160, which indicate state of mind in poor condition And to collect plasma measured by ELISA in plasma levels of 5-HT. Then use the SPSS software to statistics analysis, at last estimate the relativity of 5-HT change tendency with GDM and healthy pregnant women's mental state.Result1.The comparison of GDM and healthy pregnant women SCL90, GDM pregnant women SCL90>160(mood badness) incidence obviously higher than healthy pregnant women, P<0.05, has statistics disparity.2.Healthy pregnant women who get SCL90>160, their plasma 5-HT content obviously reduce, P<0.05, has statistics disparity, SCL90 is negative relative with plasma 5-HT level (r=-0.314, P=0.013).3. GDM pregnant women who get SCL90>160, their plasma 5-HT content obviously reduce, P<0.05, has statistics disparity, SCL90 is negative relative with plasma 5-HT level (r=-0.527, P= 0.001).4. In pregnant women who has SCL90>160, there is no statistics disparity with 5-HT level whether the women have GDM.5. In pregnant women who has SCL90≤160, there is no statistics disparity with 5-HT level whether the women have GDM.6. Use the total 100 pregnant women as investigation object, the SCL90 is negative relative with plasma 5-HT level (r=-0.394, P= 0.000)ConclusionThe pregnant women with gestational diabetes mellitus have higher SCL90 score and lower 5-HT, and more easily have mood disorder tendency. In different mood status groups, there is no statistics disparity with 5-HT level whether the women have GDM, but if SCL-90 score increases, and 5-HT decreases, GDM patients may have more serious mood disorder tendency. They need doctors, nurses and family to give more care in life and therapy. If in accordance with the actual situation, select the appropriate medical treatment of psychological intervention, it will help to control disease and reduce the incidence of postpartum depression.