Kawasaki Disease Circulating Endothelial Cells Levels Of The Relationship Between Coronary Injury

ObjectiveKawasaki disease in this study by observation (Kawasaki disease, KD) in children with circulating endothelial cells (CEC) levels in patients with coronary artery damage in children, to further explore methods of early diagnosis of Kawasaki disease.MethodsThe subjects were 30 cases of children with Kawasaki disease,23 cases of complete disease,7 cases of incomplete Kawasaki disease. Double-blind control study using human blood were gamma globulin (IVIG) treatment before blood samples were 2ml, with Hladovec method to count circulating endothelial cells. According to results of echocardiography will be Kawasaki disease were divided into groups of coronary artery lesions (CAL) 9 cases and coronary artery without injury group (NCAL) 21 cases. Control group of 10 healthy children.ResultsKawasaki disease were compared with the control group, the number of CEC: CEC quantity of Kawasaki disease group (9.77±5.45)/0.9ul, higher than the control group (3.40±1.26)/0.9ul, the difference was significant (P<0.01).Kawasaki CAL group compared with the number of CEC NCAL Group:CAL group The number of children with CEC (16.56±2.13)/0.9ul, higher than the NCAL group (6.86±3.41)/0.9ul, compared to significantly (P<0.05).Of complete and incomplete Kawasaki disease Kawasaki disease compared the number of circulating endothelial cells:complete set of Kawasaki disease in children with the number of CEC was (10.48±5.69)/0.9ul, incomplete Kawasaki disease group The number of children with CEC (7.43±4.08)/0.9ul, showed no significant difference (P> 0.05).Conclusion Acute phase of Kawasaki disease in children with significantly elevated levels of circulating endothelial cells, acute coronary artery injury group, the level of circulating endothelial cells than those without injury group, the level of detection of circulating endothelial cells contribute to early diagnosis of Kawasaki disease.