Effect Of Adjuvant Therapy Of Low-dose Triamcinolone For Hypothyroidism Caused By Autoimmune Thyroid Disease

ObjectivesTo observe the therapeutic effect of L-thyroxine (LT4) plus low-dose triamcinolone in treatment of hypothyroidism caused by autoimmune thyroid disease (AITD).MethodsTotally 60 patients with hypothyroidism caused by AITD were evenly randomized into 2 groups:L-thyroxine treatment group (group A) and L-thyroxine, triamcinolone combined treatment group (group B). The two groups were measured by serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyroglobulin antibody (TGAb) and thyroid peroxide antibody (TPOAb) before and 4 months after treatment. Group B was also measured cortisol, adrenocorticotropic hormone (ACTH), plasma glucose.ResultsAfter 4 months treatment, the levels of serum FT3, FT4, TSH were improved compared with before in both groups, but the levels of FT4, TSH of group B were improved even more evidently.The levels of TGAb and TPOAb of group A had no significant change. But decreased significantly in group B, and by the end of 4 months treatment, group B required a lower average dose of LT4 than group A.ConclusionsOral L-thyroxine plus low-dose of triamcinolone therapy can significantly reduce the levels of serum TGAb and TPOAb, and recover thyroid function faster.