The Clinical Research Of Tianjing Mingmu Therapy In Treating Age-related Macular Degeneration With Yin Deficiency Of Liver And Kidney

BackgroundAge-related macular degeneration (AMD), also known as senile macular degeneration, is a common type of retinal degeneration diseases which can seriously affect central vision. The increase in incidence is closely related to age. According to different clinical manifestations, it is divided into two types of dry and wet. Until now, the precise cause is unclear, so it has not effective therapy. AMD belongs to the category of traditional Chinese medical(TCM) science of "Shizhanhunmiao", consider that the disease is mainly related to the liver, spleen, kidney dysfunction, blood loss and as well as phlegm related illness sex-based vacuity false is mixed. Therefore, we use cooling blood Sanjie, tianjing mingmu method for the treatment of the disease, and promote blood to reconcile,Huoxuetongluo, thus contributing to macular exudation, hemorrhage and regression of choroidal neovascularization. And achieved satisfactory outcomes.ObjectiveTo observe the effection of the cooling blood Sanjie, tianjing mingmu method based traditional Chinese medicine Yin Deficiency of Liver and Kidney patients with age-related macular degeneration macular exudation, hemorrhage, and subretinal neovascularization.MethodsChose 60 patients (60 eyes) patients in TCM Hospital of Guangdong Province from October 2008 to October 2009 ophthalmology clinic of the AMD line with Yin Deficiency of Liver and Kidney, which were randomly divided into 2 groups: treatment group,30 patients (30 eyes) and a control group of 30 patients (30 eyes). Treatment group was filling a tianjing mingmu soup (Qiangen-20 grams, Cassia-15 grams, Heterophylla-15 grams, Astragalus-10 grams, Medlar-10 grams, Pinellia-10 grams, Fritillaria-15 grams, Puhuang-5 grams, Bu guzi 5 grams, Rehmannia-10 grams, Mulberry-10 grams, Eclipta alba-15 grams, Ligustrum lucidum 15 g, etc.) treatment, one agent per day; the control group was treated with Qi Ju Di Huang Wan,6g, bid. Treatment for 1 month. Before and after treatment, observe visual acuity,macular exudation under fluorescence imaging,hemorrhage,and choroidal neovascular changes under OCT.ResultsThe total effective ratio(76.67%)in the treatment group was remarkable higher than the control group(36.67%), the two groups Comparative efficacy of P<0.05, statistically significant differences between the treatment group and control group.ConclusionsLiangxue Sanjie, Tianjing Mingmu method can promote Yin Deficiency of Liver and Kidney patients with age-related macular degeneration macular exudate absorption and CNV the shrink or even disappear.