Effect Of Dexmedetomidine Hydrochloride Injection On The Stress Response During General Extubation Anesthesia

During tracheal extubation. blood pressure and heart rate increase in patients because of recovery, pain suction and cough. Anesthetics analgesics and vasodilators are often used for attenuating cardiovascular responses to tracheal extubation with the development of medicine, especially appearance of shod action drugs (such as propofol, remifentanil, and esmolol),more strategy can be used in clinic and get satisfied effects. We reviewed recent advance in the cause function. symptoms single drug and combined prevention strategy, evaluation and side-effects of prevention strategy for tracheal extubation of general anesthesia. Recently our hospital use the Dexmedetomidine Hydrochloride Injection to prevent the stress response under general extubation anesthesia get reasonable results, so we want to summarize it and provide our experience.[Objective] To investigate the effect of Dexmedetomidine Hydrochloride Injection on the stress response during general extubation anesthesia.[Methods] Forty selective surgical patients were randomly divided into two groups:group D(Dexmedetomidine) and group P (propofol). group D Dexmedetomidine 0.8ug/kg was given i.v.10 min before induction of anaesthesia, during surgery Dexmedetomidine was given 0.2～0.7ug/kg/hr to maintain anesthesia other durg and group P were under general anesthesia. The individuals with coronary heart disease, difficult for intubation, central nervous system disease, septemia, hepatosis, renal dysfunction, dyshormonsism were ruled out. The time of fasting solid was more than 12 hours and fluid was more than 4 hours. Atropine 0.5mg was intramascular injected at 30 minutes before operation. After opening the venous channel, Ringer lactate solution and 6%hydroxyethyl starch with the proportion of two to one were infused to maintain anesthesia. The blood pressure (BP), heart rate (HR), electrocardiogram (ECG) and blood oxygen saturation (SPO2) of all patients were recorded successive during the surgery. In two groups, the SBP,DBP,HR,SPO2 were recored at time points before induction (T1),the end of intubation (T2),the time of 5min after extubation (T3) and the time of 15 min after extubation (T4).The arterial blood gas analysis,the venous blood of cortisol (COS) and blood sugar (BGa) were recored at T1,T2,T3,T4.[Results] In group P, the MAP and HR during extubation obviously decreased, lower than the level before extubation. During the same period, in group D, the MAP and HR after extubation increased unobviously(P<0.01). The blood glucose and corticosteroid obviously increased at T3 than T1 (P<0.05). Group comparison obviously increased at group P than group D(P<0.05).[Conclusion] Dexmedetomidine Hydrochloride Injection can prevent the stress reaction during extubation and patients were quiet...