Analysis Of Serum Lipid Levels Among Female Patients Before Percutaneous Coronary Intervention And The Relationship Between The Syntax Score

Objective:We retrospectively investigated the serum lipid levels among female coronary artery disease (CAD) patients before percutaneous coronary intervention (PCI) and analyze the serum lipids according to Syntax scores. The relationships between lipids level and syntax scores in female CAD patients were evaluated.Methods:A consecutive 246 patients (67.29±8.14 years old) with CAD before PCI were enrolled in this study. The patients were divided into STEMI and non-STEMI (NSTEMI and UAP) group and serum lipid levels before PCI were analyzed with Syntax scores. The Syntax score was calculated according to the results of coronary artery angiography (CAG). All of the patients were not underwent lipid-lowering therapy before in-hospitalization. The severity of coronary artery disease were divided into 3 Syntax score groups according to the Syntax scores in all patients, light score group (Syntax score≤22), moderate score group (Syntax score 23-32), and severe score group (Syntax score≥33). The lipids such as TC,HDL,LDL,non-HDL,ApoA1,ApoB,LP(a),TG were studied in every groups. The relationships between lipids level and Syntax score groups in female CAD patients were evaluated.Results:Baseline clinical characteristics and lipid levels were different between STEMI and non-STEMI patients. The mean age was older in STEMI compared to non-STEMI(69.70±8.58 vs 66.58±7.89 years, P< 0.05), prior Stroke was higher in STEMI compared to non-STEMI(19.6% vs 6.3% P<0.05). Both ApoAI and TG was lower in STEMI compared to non- STEMI(116±18 mg/dl vs 123±27 mg/dl, P<0.05, and 113.72 mg/dl vs 161.95 mg/dl, P<0.05). The lipid levels among light lesion,moderate lesion and severe lesion were no differences in the group of acute ST-elevated myocardial infarction (P> 0.05). The level of LP(a) in light lesion was lower than the moderate lesion in the group of non-ST-elevated myocardial infarction (144.84mg/L vs 220.24 mg/L,P<0.05). The level of ApoB/ApoAI in light lesion was lower than the severe lesion in the group of non-ST-elevated myocardial infarction (0.67±0.24 vs 0.83±0.49,P< 0.05)Conclusion:1. Baseline clinical characteristics and lipid levels were significantly different between STEMI and non-STEMI patients. For the group of STEMI patients, older age,higer prior Stroke were the most significant clinical characteristics. For the group of STEMI patients, low ApoAI was the most significant dyslipidemia; for the group of non-STEMI patients, High TG was the most significant dyslipidemia.2. The severity of Syntax scores were no differences between STEMI and non-STEMI PCI female patients.3. The lipid levels among light lesion,moderate lesion and severe lesion were no differences in the group of acute ST-elevated myocardial infarction.4. The LP(a) levels in moderate lesion and the ApoB/ ApoAI in severe lesion were increased in the group of non-ST-elevated myocardial infarction. We suggest that LP(a) and ApoB/ApoAI are the most important risk factors in female CAD(non-STEMI) patients.