Clinicopathological Characteristics Of Familial Gastric Cancer And Expression And Significance Of Desmoglein 2

Objective:This study was to observe familial clinical and pathological characteristics of familial gastric cancer, examine the expression of desmoglein 2 in familial gastric cancer and investigate the relationship between desmoglein 2 and development and invasion in familial gastric cancer.Methods:We retrospectively analyzed 34 cases of familial gastric cancer and 100 cases of sporadic gastric cancer which were randomly selected to observe the differences between the two teams in clinical and pathology. Immunohistochemical method was used to detect the protein expression of desmoglein 2 in 34 cases of familial gastric cancer and 34 cases of sporadic gastric cancer which were randomly selected. All cases were collected in the first affiliated hospital of Dalian medical university from 1998 to 2008.Results:Comparing the clinical data of familial gastric cancer cases and sporadic gastric cancer show:There were significant differences between familial and sporadic gastric cancer in age, depth of invasion, clinical stage, histological type, Lauren type, lymph node-positive rate and the scope of lymph node metastasis (p<0.05).There were not significant difference in the tumor site (p=0.440) and tumor size (p=0.315). Survival analysis showed that the familial gastric cancer patient survival rate was significantly lower than in sporadic gastric cancer (p<0.05). Multivariate analysis showed that age, depth of invasion, histological type, Lauren type, tumor stage was independent factors in familial gastric cancer (p<0.05), while gender (p=0.421), tumor location (p=0.315), node-positive rate (p= 0.841) and the expression of Dsg2 style 0=0.351) are not independent factors. Immunohistochemical analysis showed that 13 cases of normal expression,9 cases of abnormal expression of moderate and 12 cases of severe abnormal expression in 34 cases of familial gastric cancer. There were 24 cases of normal expression,6 cases of abnormal expression of moderate,4 cases of abnormal expression in 34 cases of sporadic gastric cancer. The expression pattern of Dsg2 was significantly different between familial gastric cancer and sporadic gastric cancer, diffuse and intestinal type of gastric cancer (p<0.05).However, there were no significant differences between familial diffuse gastric cancer and sporadic diffuse gastric cancer (p=0.352), familial intestinal type of gastric cancer and sporadic intestinal gastric intestinal(p=0.415).In familial gastric cancer, the expression pattern of Dsg2 was related with tumor size and histological type (p<0.05),while not related with age (p=1.000), gender (p=1.000), tumor location (p=0.290), clinical stage (p=0.077), depth of invasion (p= 0.450) and lymph node metastasis(p=0.932).Conclusions:Familial gastric cancer clinical and pathological characteristics were:early age of onset; poor histological type, more diffuse type; earlier lymph node metastasis, high rate of transfer; rapid development and poor prognosis. The expression of Dsg2 significantly decrease in patients of familial gastric cancer and diffuse gastric cancer, which play a role in the mechanism of familial gastric cancer, especially in the growth and development of tumor.