Expression And Relationship Between PTEN And Survivin In Bladder Urothelial Carcinoma

Objective:To investigate the protein expression and interrelation between the tumor suppress gene PTEN and apoptosis suppress gene Survivin in bladder urothelial carcinoma as well as to investigate the relationship and clinic significance of PTEN, Survivin in grade, stage and prognosis in bladder urothelial carcinoma.Methods:The expression of PTEN and Survivin protein were detected by S-P immunohistochemistry technique in 60 cases of bladder urothelial carcinoma and 10 cases of normal bladder mucosa. statistics analysis was progress with SPSS13.0 package.Results:(1) All 10 cases normal bladder tissues had positive express-ion of PTEN.8 cases colored caryon and 3 cases colored cytoplasm.21 positive expression in 60 cases bladder urothelial carcinoma. There was obviously statistically significantly differences of PTEN protein positive between bladder urothelial carcinoma and nomal bladder tissues (P<0.01). There was statistical significance in lower grade and higher grade, non-invasive and invasive, primary and recurrent cases(P<0.05). There was no statistical significance in single occurrence and multi-occurrence, non-lymphoid node metastasis and lymphoid node metastasis cases(P>0.05). The higher the grade, stage and recurrent of tumor was,the lower the expression of PTEN protein. (2) All 10 cases normal bladder tissues had not positive expression of Survivin protein.42 cases Survivin protein colored caryon in 60 cases bladder urothelial carcinoma. There was obviously statistically significantly differences of Survivin protein positive between bladder urothelial carcinoma and nomal bladder tissues(P<0.01).There was statistical significance in lower grade and higher grade, non-invasive and invasive, single occurrence and multi-occurrence, primary and recurrent cases (P<0.05). There was no statistical significance in non-lymphoid node metastasis and lymphoid node metastasis cases(P>0.05). The higher the grade,stage,quantity, and recurrent of tumor was,the higher the expression of Survivin. (3) There was obviously statistically significantly differences between PTEN protein negative expression and simultaneous Survivin protein positive expression in bladder urothelial carcinoma (P<0.01).Conclusion:The positive expression of the PTEN protein was a obviously negative correlation between in urothelial carcinoma of the bladder and in normal bladder tissues.The close relationship was found between the abnormal expression of PTEN, Survivin protein and the behavior in biology of the urothelial carcinoma of the bladder. PTEN and Survivin had the synergism.There was a negative correlation between the positive expression of the PTEN protein and malignancy degree, stage and prognosis of urothelial carcinoma of the bladder. The abnormal expression of Survivin is common in urothelial carcinoma of the bladder and there was a positive correlation between the positive expression of the Survivin protein and malignancy degree, stage and prognosis of urothelial carcinoma of the bladder.The expression of PTEN and Survivin protein presented significantly negative correlation.The coexpression of survivin and PTEN had invariably reference value in diagnosis, malignant degree and prognosis in urothelial carcinoma of the bladder.