Analysis Of Prognostic Factors Of LGG Treated By Postoperative Radiotherapy

Objective Retrospectively analyzed the 3-year survival rate and the factors of low-grade glioma treated by postoperative radiotherapy.Methods Retrospectively analyze 101 patients of LGG treated by postoperative radiotherapy,who were treated in the Shanxi Tumor Hospital. Analysis of the ten Prognostic factors, which gender, age, with or without seizures, pathological type, postoperative radiotherapy waiting time for radiotherapy the KPS score, tumor size, extent of surgical resection, radiotherapy dose, if combined with chemotherapy。44 patients received total resection,57 received subtotal resection,including 60 patients had chemotherapy,median waiting time from operation to radiotherapy was 24 days, radiation dose between 40-60Gy.Calculating survival rate by K-M,the Log-rank test was used for univariate analysis,COX model was used for multivariate analysis.Results The 1-year and 3-year overall survival rate were 91%and 70%,Univariate analysis showed:gender (P= 0.254), whether the seizures (P= 0.249), pathologic type (P= 0.085) and postoperative radiotherapy waiting time (P= 0.519), in accordance with a= 0.05 standard, P> 0.05.To low grade gliomas the prognosis of postoperative radiotherapy,they were had no statistical significance, that has nothing to do with the 3-year survival rate; KPS score (P= 0.01), tumor size (P= 0.002), extent of surgical resection (P< 0.000), the dose of radiotherapy (P= 0.008), age (P<0.000), whether the combination chemotherapy (P= 0.007) was an important factor affecting the 3-year survival rate. Multivariate analysis showed that KPS score before radiotherapy (P= 0.034), extent of surgical resection (P= 0.001), radiotherapy dose (P= 0.013), age (P<0.000) was the independent factors of affecting the 3-year survival rate of low-grade glioma treated by postoperative radiotherapy;combination of the groupings we can see higher KPS score, the patient has the better general situation, they will have the better prognosis; the patients prognosis,who had tumor total resection and radiotherapy doses between 54-60Gy, is better than the subtotal resection and radiotherapy doses<54Gy of patients; rising with age, the prognosis is relatively poor. Surgery methods on 3-year survival rate is greater than the impact of radiation dose on it (P＜0.05) Conclusion Age<40 years,KPS before radiotherapy≥70,total resection and radiation dose between 54-60Gy are the better factors.