Abnormalities During The Resting State Functional Magnetic Sonance Imaging In Treatment-naive Major Depression Disorder

Objective:We explored differences of brain spontaneous activity in resting state between depression, degree-first and controls using function magnetic resonance imaging (fMRI) in order to find the base of neural activity in depression associated with phathophysiological mechanism.Methods:51 subjects with depression and 50 sex, age and education-matched controls underwent 3 min and 40 sec fMRI scans while resting state. ReHo and ALFF analysis were used to detect neural spontaneous activity across the whole brain by REST. Two within-group analysis was performed among two groupes by t-test (P<0.001) by SPM5.Results:1.subjects:there were no significant differents among MDD as well as control respect to age and gender as well as education.2. fMRI results:2.1 ReHo analysis:The ReHo of bilateral medial frontal gyrus were significantly increased in resting state in depression compared to control;2.2 ALFF analysis:The ALFF of right medial frontal, right cingulate gyrus were significantly increased in resting state in depression compared to controls.Conclusion:1. Compared to controls,the depressed patients showed the increased ReHo in bilateral medial frontal gyrus, which implicated the increased regional homogeneity of these regions may be the neuropathotogical substrate in depression;2.The depressed patients showed the increased ALFF in right medial frontal, right cingulate gyrus, which implicated the increased amplitude of regional activity in these regions may be the neuropathotogical substrate in depression;3.The depressed patients showed the increased both ReHo and ALFF in right medial frontal gyrus, the present result implicate that these regions play a importance role in mechanism of neuropathotogical in depression.