Effect Of Early Statin Intervention On Serum Pregnancy-associated Protein-A And C-reactive Protein Levels In Patients With Acute Coronary Syndrome

Objective:To confer the pregnancy-associated protein-A (PAPP-A) and C-reactive protein (CRP) level changes of patients with ACS, effects of rosuvastatin and simvastatin on PAPP-A and CRP levels were analyzed, which direct the treatment of patients with ACS with rosuvastatin.Materials and methods:All 110 patients complaining chest pain within one week who were suspected as coronary heart disease according to coronary heart disease diagnostic criteria which was formulated by Chinese Medical Association in 2007 were confirmed by the results of coronary angiography group,which were divided into four groups:of which 20 patients with normal coronary angiography for the the control group, stable angina (SAP) 30 patients with acute coronary syndrome group (ACS) 60 cases.Sixty patients with ACS of all were randomly divided into rosuvastatin group and simvastatin group. Two to four milliliter venous blood was collected from each subjects admitted to hospital and the blood samples were divided into two parts:one part for hospital clinical laboratory testing, the other was centrifuged 1000 r/min for 15min, then the supernatant collected and preserved in refrigerator at-80℃until PAPP-A and CRP levels detection. Two weeks after the intervention, venous blood samples were collected again. In order to avoid the inter-error and measurement error, the test was done in a one-time batch until sample collection was completed. SPSS12.0 analysis software system was applied for the statistical analysis.Results:1.Before intervention, the PAPP-A level of rosuvastatin group and simvastatin group was(20.1±10.8,(19.3±10.1) mIU/L,the CRP level was(9.3±1.1),(8.7±1.5) mg/L,respectively, the PAPP-A level of SAP group and the control group was(7.6±3.1),(7.2±2.3)mIU/L,,the CRP level was(2.7±0.1),(2.4±0.3)mg/L,respectively.PAPP-A and CRP levels in patients with ACS were significantly higher than patients with SAP and control group patients before intervention(P<0.01). While no obvious difference was found between with rosuvastatin treatment and simvastatin treatment patients(P>0.05). So were the SAP patients and the control patients.2.After the agent intervention, the PAPP-A level of rosuvastatin group and simvastatin group was(12.7±1.1),(14.3±2.5)mIU/L,the CRP level was(3.2±0.4),(4.4±0.8)mg/L,respectively. Compared with each test indicator before the agent intervention, the indicators in the rosuvastatin and the simvastatin groups after the agent treatment were significantly different (P<0.01).There was obvious difference in the various indicators between rosuvastatin group and the simvastatin group after the agent intervention (P<0.05).Conclusions:Though comparative study of rosuvastatin and simvastatin on PAPP-A and CRP levels in patients with ACS, we concluded that, PAPP-A and CRP levels in patients with ACS were significantly greater than the other group; rosuvastatin and simvastatin can significantly reduce the PAPP-A and CRP levels in patients with ACS;the PAPP-A and CRP levels of rosuvastatin group were significantly lower than the simvastatin group.