Protective Effects Of Lcarnitine On Myocardium In Patients Undergoing Open Cardio-pulmonary Bypass

Objective:To investigate the effect of Lcarnitine on myocardial enzymes in patients with Congenital Heart Disease (CHD) undergoing open cardiac operation with cardio pulmonary bypass(CPB). Method:40 patients with CHD were randomly divided into two groups, Test group and Control group (n=20 in each group). Lcarnitine was put in the cold ST. ThomasE crystal cardiac arresting liquid in the test group, Other experimental conditions w ere the same between two groups. Before operation,20 minutes after the aortic clamping and at 1h,2h,6h,24h after the aorticdeclamping, venous blood was drawn to test the level of serum creatine kinase (CK) and CK-MB isozyme.Results:The level of CK and CK-MB had no difference between 2 groups before operat ion. From the end of CPB, the level of CK and CK-MB were significantly lower in the Test group than that in the Control group (P<0.05). Conclusion:Lcarnitine as an ingredient of cardioplegia solution has a good pro tective effect on myocardium in patients with CPB.