Experiment Study On The Expression Of P21-activated Kinase In Human Chondrosarcoma

PAK takes one important living thing adjustment factor, in many organizations widespread expression, has the influential role in the mammal a series of cell function, for example:The cell movement, the cell survival, the mitotic cycle, the blood vessel production, the gene duplication adjustment and the tumor occurrence develops and makes a sneak attack shifts. PAK1 is a important memberin PAK family's, may the signal activates by outside the growth factor and other butchers through the GTP enzyme dependence signal passage or the non-GTP enzyme dependence signal passage, display many kinds of biology effects. The research indicated that the ovary epithelioma and the colon cancer, in the mammary gland tumor, liver cancer expresses the obvious markup. PAK1 exceptionally expresses, possibly causes the tumor occurrence, the development, the invasion and the migration.PurposeWe used immunohistochemistry streptavidin-peroxidase staining to obverse the expression of PAK1 in human chondrosarcoma tissue,so that further understand the relationship between PAK1 and the chondrosarcoma occurrence, the development relations.MethodsExpression of PAK1 in 29 chondrosaroma cases and 25 osteochondroma to contrast by HE staining and S-P immunohistochemistry.We choose four fields of view in random,then count 100 masculine cell.The results are analyzed by statistics.ConclusionPAKl obviously expresses high level in osteochondroma, and the difference has statistical significancal significance.Suggest that PAK1 is related to chondrosarcoma occurrence, development and invasion.