A Study Of The Time Changes And Clinical Significance Of S100B Protein And NSE In Serum With HIE Patients

Objective:To investigate the time changes and clinical significance of S100B protein and NSE in serum with HIE patients.Methods:The levels of S100B protein and NSE in serum were detected in 50 full-term newborn infants with HIE on the first, third and seventh day after birth.60 normal newborns were enrolled into the control groups.Results:①The serum S100B levels of HIE neonates was significantly higher in samples collected throughout the monitoring period than those of the normal control groups(all P<0.05).The serum NSE levels of HIE neonates was also siginificantly higher than that of normal samples within the monitoring days (P<0.05). (2)A significantly positive correlation was found between the level of serum S100B protain and NSE in all the monitoring days(P<0.05).③When S100B concentration was 0.17ug/L and NSE was 8.5ug/L, the sensitivity and specificity of detecting the third day serum S100B protain were respectively 91.3%和92.9%.Detecting it associated with the third day serum NSE level could increase the sensitivity and specificity (respectively 97.4%和95.1%) for predicting development of HIE.Conclusion:On the basis of clinical manifestations of asphyxic neonatals, detecting the level of serum S100B protain and NSE in the third day after birth may be of important value in early diagnosis and grading of HIE.