Experimental And Clinical Research Of Kidney-invigorating, Blood-promoting And Phlegm-dissipating In Vascular Dementia

Objective:Experimental and clinical observation of Kidney-invigorating, Blood-promoting and Phlegm-dissipating in vascular dementia (VD) mice, to explore the mechanism of prevention and treatment VD.Methods:Experimental study The models of VD mice were established by cerebral ischemia reperfusion, All the mice were divided randomly into five groups:sham-operated group, model group, Hydergine group, high-dose of Naolisu capsule group, low-dose of Naolisu capsule group. To observe body weight change in mice, after 15 days later, The influence of cerebral ischemia reperfusion on behaviors of mice was studied by step down test. The levels of brain-derived neurotrophic factor(BDNF), superoxide dismutase(SOD) and malondialdehyde(MDA) were analyzed with biochemistrical analysis method.Clinical observation Study 40 patients who suffered from vascular dementia, all the people were divided randomly into treatment group and control group, and case-control study on them. Two groups have conventional treatment:The control group was treated with Hydergine (Po, 1mg/time, Tid), The treatment group was treated with Hydergine and Naolisu capsule (Po, 200ml/time, Tid). The total course of treatment was 12 weeks, each treatment group were 4 weeks. We observed the safety and efficacy in patients. we used syndrome differentiation scale of vascular dementia(SDSVD), mini-mental state examination(MMSE) and activity of daily living scale(ADL) to evaluate the state of patient.Results:Experimental study There is a transient lowering of body weight, after one week it begin to rise. Repeated cerebral ischemia reperfusion showed more severe impairment of learning and memory than that of treatment groups(p<0.05), the activity of SOD and BDNF obviously increased in treatment groups, the content of MDA reduced in treatment groups(p<0.05), The most obvious is low-dose of capsule group.Clinical observation The treatment group was better than the control group in scores and clinical effectiveness. With the time increasing, The treatment group was more effective than the control group, (p<0.05).Conclusions:The Kidney-invigorating, Blood-promoting and Phlegm-dissipating could improve the growth status, and their nervous self-protection and anti-oxidation ability in mice. It may be one of the mechanisms to treatment VD. Clinical observations confirm Naolisu capsule not only improve patient with intellectual disabilities, reduce bad symptoms, enhance the patient activities of daily living and the role of quality of life. It also reduce the blood pressure, lowering serum total cholesterol, and increase the role of high density lipoprotein.