Changes Of Cardiac Structure And Function In Patients With Hypertension Disorders Complicating Pregnancy

Objective:To investigate the influence of hypertensive disorders complicating pregnancy to patients'cardiac structure and function, and the correlation of echocardiography and each index of hemorrheology and blood lipid and myocardial enzymes.Methods:The observation group contains patients with hypertensive disorders complicating pregnancy, among this severe pre-eclampsia and eclampsia is intensive group and mild pre-eclampsia is light disease group, the control group contains normal pregnant women.1,every cases were required to do echocardiography, compare the interventricular septum thickness(IVST), left ventricular diastolic diameter (LVD), left ventricular internal diameter end closing (LVS), left ventricular posterior wall thickness (LVP-WT), left Room diastolic volume (LEDV), anteroposterior diameter of right ventricle (RA), ejection fraction (EF) of every group to see if they have difference.2, the observation group were required to do hemorheology, blood lipids, myocardial enzymes, Analyses the correlation between blood biochemical and echocardiography.Results:1, Comparison results of cardiac structure and function between groups: Interventricular septum thickness (IVST), left ventricular diastolic diameter (LVD), ejection fraction (EF):(1) There was significantly differences between intensive group and light disease group;(2) There was significantly differences between intensive group and control group;(3) IVST in light disease group and control group had no significant difference, EF in light disease group and control group had significant differences;Other indexes of echocardiography had no difference between these groups.2, The correlation of echocardiography and hemorheologyLeft ventricular diastolic volume (LEDV) and red cell rigidity index was negatively correlated, with the increase of red cell rigidity index, left ventricular diastolic volume showed a decreasing trend.Left ventricular diastolic volume (LEDV) and red cell deformability index was positively correlated, and with the increase of erythrocyte deformation index, left ventricular diastolic volume tended to increase.Anteroposterior diameter of right ventricle (RA) was negatively correlated with erythrocyte sedimentation rate, and with the increase of ESR, anteroposterior diameter of right ventricle had a decreasing trend;The rest index of hemorheology and echocardiography showed no significant difference between groups.3, The correlation of echocardiography and blood lipid:Ejection fraction (EF) and triglyceride (TG) were negatively correlated, with the increase of TG, EF had a decreasing trend.Ejection fraction (EF) and high density lipoprotein (HDL) was positively correlated, and with the increase of HDL, EF tended to increase.Ejection fraction (EF) and total cholesterol (TC) was negatively correlated, and with the increase of TC, EF tended to decrease.Anteroposterior diameter of right ventricle (RA) and total cholesterol (TC), triglyceride (TG) was positively correlated, that is, with the increase of TC, TG, RA tended to increase. Anteroposterior diameter of right ventricle (RA) was negatively correlated with high density lipoprotein (HDL), with the increase of HDL, RA had a decreasing trend.4, The correlation of echocardiography and myocardial enzymes: Left ventricular diastolic volume (LEDV) and hydroxybutyrate dehydrogenase (HDB) was negatively correlated, with the increase of hydroxybutyrate dehydrogenase (HDB), the left ventricular diastolic volume showed a decreasing trend. Anteroposterior diameter of right ventricle (RA) was negatively correlated with creatine kinase (CK) and hydroxybutyrate dehydrogenase (HDB), with the increase of CK, HDB, the left ventricular diastolic volume showed a decreasing trend. Ejection fraction (EF) and lactate dehydrogenase (LDH) were negatively correlated. with the increase of LDH, left ventricular diastolic volume showed a decreasing trend.Conclusion:1,Among the index of echocardiography, interventricular septum thickness (IVST) is a sensitive indicator to reflect cardiac structure, with the increase of the severity of hypertensive disorders complicating pregnancy, IVST had a tendency to thicken. EF is a sensitive indicator to reflect cardiac function, with the increase of the severity of hypertensive disorders complicating pregnancy, EF had a tendency to decrease.2, Hemorheology reflects blood viscosity and fluidity, among them erythrocyte rigidity index, erythrocyte deformation index, and erythrocyte sedimentation rate are more sensitive, with the incease of erythrocyte rigidity index, the decrease of erythrocyte deformation index and the acceleration of ESR. left ventricular diastolic volume had a tendency to increase.3, Blood total cholesterol, triglyceride, low density lipoprotein is the main influential factors of blood viscosity, with the increase of total cholesterol, triglycerides, low density lipoprotein, EF had a decreasing trend, anteroposterior diameter of right ventricle tended to increase. HDL plays a physiological role in transplanting cholesterol from extrahepatic tissues to the liver, so it can reduce blood viscosity, with the increase of high density lipoprotein, ejection fraction had a tendency to increase, anteroposterior diameter of right ventricle (RA) had a tendency to decrease.4, Myocardial enzymes are present in myocardial cells, increased myocardial enzymes reflecting myocardial cell damage. With the increase of lactate dehydrogenase, ejection fraction had a decreasing trend. With the increase of CK, anteroposterior diameter of right ventricle tended to increase.